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You've tracked your macros in MyFitnessPal, stacked your supplements on the kitchen counter, and still feel like something's missing from your weight management routine. The ageLOC TRMe & R² 90-Day Kit ($1,446.15) is built for exactly that person — the structured, routine-driven American who isn't dabbling but has committed to a real 90-day body composition effort. Whether you're a Chicago professional blocking out Q1 for a health reset, or a Dallas gym-goer who wants science-backed support layered beneath their training plan, this is Nu Skin's most comprehensive bundle: six distinct products addressing appetite, metabolic rate, emotional cravings, protein nutrition, daytime cellular energy, and overnight cellular purification — all running simultaneously for three months.
This kit bundles three months of the full TRMe weight management system with three months of R², Nu Skin's day-and-night cellular vitality protocol — 18 boxes total across six product lines.
Most weight management supplement stacks stop at appetite suppression and a protein shake. This kit goes further by addressing what happens at the cellular level when your body is running on a calorie deficit.
When you're burning stored fat, your body generates metabolic byproducts that need to be cleared efficiently. R² Night's milk thistle and broccoli seed extract support the detoxification pathways responsible for that clearance — the kind of cellular housekeeping that becomes more important, not less, during periods of active fat metabolism.
On the energy side, running a sustained calorie deficit while exercising demands more efficient mitochondrial output from less fuel. Cordyceps Cs-4 in R² Day is the same standardized extract used in Nu Skin's standalone ageLOC® R² Day — supporting cellular energy production when your intake is intentionally lower than your output. The addition of pomegranate extract and chokeberry provides antioxidant support for cells under the oxidative stress of increased metabolic activity.
The rationale for pairing R² with TRMe is straightforward: weight management programs are among the most metabolically demanding things you can ask your body to sustain. This kit treats that demand as a full-system challenge rather than a single-variable equation.
Organize capsules into four daily groups for manageable compliance:
Total: approximately 12–14 capsules/sachets daily plus the protein shake. A weekly pill organizer with morning/midday/evening/bedtime compartments is strongly recommended for daily compliance over 90 days.
| Product | System Scope | Cellular Energy Support | Overnight Purification | Protein Component | Protocol Duration |
|---|---|---|---|---|---|
| ageLOC TRMe & R² 90-Day Kit | 6-product: appetite, metabolism, mood, protein, cellular energy, cellular purification | Cordyceps Cs-4 + pomegranate (standardized extract, daytime) | Milk thistle + broccoli seed + curcumin (dedicated overnight capsule) | 15g plant protein per serve, included | 90 days, full protocol |
| Thorne Metabolic Health Bundle | 2–3 products: berberine, basic multivitamin | No dedicated cellular energy formulation | No dedicated overnight formulation | Sold separately | Open-ended, no structured protocol |
| Garden of Life Fit Weight Loss Kit | Protein + probiotic; limited appetite/metabolism components | No dedicated mitochondrial support | No overnight detoxification formulation | Organic plant protein, included | Open-ended; no day/night protocol |
| NOW Foods Weight Management Stack (DIY) | Individual components purchased separately; no unified protocol | Basic CoQ10 available separately | Milk thistle available separately, not formulated as overnight protocol | Whey or plant protein, purchased separately | No structured 90-day system |
Comparison reflects formulation structure and ingredient specificity, not a price or efficacy ranking. Individual components from competitor brands are available but not combined into a unified day/night cellular protocol alongside a weight management system.
The ageLOC TRMe & R² 90-Day Kit ships from Nu Skin's official US warehouse. Delivery typically takes 3–5 business days across the continental United States. Customers in Alaska and Hawaii should allow additional transit time. No international shipping fees apply to domestic US orders.
No membership is required. You can purchase this kit directly through this store without signing up for any subscription or brand affiliate program.
R² is optional — the TRMe system (Slim-S, SmartWin, MyTriumph, Protein) functions as a complete, standalone weight management protocol. R² Day and R² Night add cellular energy production support and overnight detoxification support for users who want comprehensive coverage during the metabolically demanding period of active weight management, particularly those exercising regularly during the program.
Approximately 12–14 capsules and sachets daily, plus one protein shake. This is the most capsule-intensive protocol in the Nu Skin range. Organizing doses into a weekly pill organizer with morning, midday, evening, and bedtime sections makes daily compliance significantly more manageable across 90 days.
Yes. SmartWin contains naturally sourced caffeine from green tea EGCG and guarana. If you are sensitive to caffeine, have a cardiovascular condition, or are taking medications that interact with stimulants, consult your healthcare provider before starting this program.
You can, but it's a significant commitment — both financially and in daily protocol complexity. If you are new to TRMe, the ageLOC TRMe 30-Day Kit allows you to evaluate whether the structured approach fits your lifestyle before committing to 90 days. Most customers investing at this level have prior experience with Nu Skin supplements.
The four core TRMe components — Slim-S, SmartWin, MyTriumph, and Protein — are identical in both kits. The difference is the companion system: the ageLOC TRMe 90-Day Kit with Nu Biome® pairs TRMe with gut microbiome support, while this kit pairs TRMe with R²'s cellular energy and purification protocol. The right choice depends on whether your priority is gut health support or cellular energy and detoxification support during weight management.
Yes. Consult your healthcare provider before beginning any weight management supplement program, especially if you are pregnant, nursing, taking prescription medications, or managing a chronic health condition. This is particularly important given the caffeine content in SmartWin and the multi-supplement nature of this protocol.
*Independent Nu Skin Brand Affiliate — not produced or endorsed by Nu Skin Enterprises Inc.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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