ageLOC® R2 Night + Day (USA)

ageLOC R² is a day-and-night supplement system that targets cellular energy production during waking hours and supports the body's natural detoxification processes overnight. At US$118.00 for a 30-day supply of both formulas, it sits above mainstream options like AG1 or Ritual — but it's one of the few supplements that separates active ingredients into circadian-aligned doses rather than packing everything into a single morning serving. If you've been stacking three or four different supplements and still feel like your energy crashes by 3 PM, R² takes a different approach.

What Makes ageLOC R² Different

The core idea behind R² is that your body has different needs during the day versus at night. During the day, you need efficient mitochondrial energy production — the cellular engines that convert food into ATP. At night, your cells need to clear metabolic waste and repair. Most supplements ignore this distinction entirely. AG1, Ritual, and Thorne's multivitamins deliver everything in a single dose and let your body sort it out. R² splits its formula into Day (energy production) and Night (cellular purification), each taken at the appropriate time.

Nu Skin's gene expression research identified specific pathways involved in age-related cellular decline. R² Day targets mitochondrial efficiency using Cordyceps Cs-4, a cultured strain with documented effects on cellular ATP production. A 2019 study in Frontiers in Pharmacology confirmed Cordyceps Cs-4 supports cellular energy metabolism through multiple pathways — not through stimulant mechanisms like caffeine, but through actual mitochondrial support. R² Night uses milk thistle (silymarin) and broccoli seed extract (a sulforaphane precursor) to support Phase II detoxification enzymes, helping your body process and clear cellular waste during sleep.

One honest caveat: R² isn't a stimulant, and it doesn't work like a cup of coffee. You won't feel a noticeable buzz 30 minutes after taking it. The effects build over 2-4 weeks of consistent use, and they're subtle — more like "I stopped hitting that afternoon wall" than "I feel wired." If you're looking for immediate energy, this isn't the right product.

Key Ingredients

R² Day:

Cordyceps sinensis Cs-4 — a standardized cultured cordyceps strain used in traditional Chinese medicine for centuries. Modern research confirms it supports mitochondrial ATP production and oxygen utilization. A randomized controlled trial published in the Journal of Alternative and Complementary Medicine (2010, PMID: 20804368) showed improved aerobic capacity and endurance in healthy adults after 3 weeks of supplementation.

Pomegranate extract — rich in punicalagins and ellagic acid, which support mitochondrial biogenesis (the creation of new mitochondria). A 2016 study in Nature Medicine (PMID: 28218021) identified urolithin A, a pomegranate metabolite, as a mitochondrial renewal activator.

Chokeberry (Aronia) extract — one of the highest-ORAC-value berries, providing anthocyanin antioxidants that protect mitochondrial membranes from oxidative stress during energy production.

R² Night:

Milk thistle extract (silymarin) — the most-studied liver-support compound in supplement science. A 2020 meta-analysis in Phytotherapy Research confirmed its hepatoprotective properties across 16 clinical trials. Supports Phase I and Phase II liver detoxification.

Broccoli seed extract — a concentrated source of glucoraphanin, which converts to sulforaphane in the body. Sulforaphane activates the Nrf2 pathway, your body's master switch for antioxidant defense enzymes. Research published in Cancer Prevention Research (2014, PMID: 24913818) demonstrated sulforaphane's role in enhancing detoxification of airborne pollutants by 61%.

How to Use

Take 2 R² Day capsules with breakfast each morning. Take 2 R² Night capsules 30 minutes before bed. That's it — roughly 10 seconds morning and night. Don't take Day capsules in the evening (the Cordyceps may keep you alert) and don't skip the Night capsules because the purification cycle is when your body clears the metabolic waste generated during the day.

Most users report noticing a difference in sustained afternoon energy within the first 7-14 days. The full cellular renewal effects build over 30-90 days of consistent use. If you're already taking a standalone NAD+ supplement like Tru Niagen, you can use R² alongside it — they work through complementary pathways (R² targets mitochondrial efficiency, NAD+ precursors target the coenzyme itself).

How It Compares

Comparison based on publicly available product information as of 2026. Features and formulations may change.

Who Is This For

Ideal for: Adults over 35 noticing declining energy, slower recovery, or that general "I just don't bounce back like I used to" feeling. Particularly relevant if you've tried individual supplements (CoQ10, B vitamins, NAD+ precursors) without meaningful results — R² combines multiple cellular pathways into one system instead of piecemeal supplementation.

Also suited for: People already deep in the supplement stacking culture who want to consolidate. If your nightstand looks like a pharmacy counter with separate bottles for energy, detox, and antioxidants, R² replaces several of those with one coordinated system.

Not recommended for: Anyone under 25 whose cellular energy production is still at peak efficiency — you likely won't notice a difference. Also not the right starting point if you haven't addressed sleep, hydration, and basic nutrition first. No supplement fixes a fundamentally broken lifestyle.

Frequently Asked Questions

Can I buy ageLOC R² in the US without signing up?
Yes. NuBest Skin sells R² with no Nu Skin membership, no registration, and no auto-ship commitment. Add to cart and check out — it ships from the official Nu Skin warehouse in the United States.

How does R² compare to just taking a standalone NAD+ supplement like Tru Niagen?
Different mechanisms. Tru Niagen provides nicotinamide riboside, a precursor that your body converts to NAD+. R² Day targets mitochondrial energy production through Cordyceps and pomegranate extract, while R² Night supports cellular detoxification. They're complementary, not interchangeable — some users take both. If budget forces a choice, consider what you need more: cellular energy support (R²) or NAD+ replenishment (Tru Niagen).

I'm already taking AG1 in the morning. Can I add R² Day on top of that?
Yes. AG1 is primarily a greens powder with broad micronutrient coverage. R² Day's Cordyceps and pomegranate extract don't overlap significantly with AG1's formula. Take AG1 first, then R² Day capsules with the same breakfast. For R² Night, take it at bedtime as usual.

Will R² Day keep me awake if I take it too late?
It's not a stimulant like caffeine, but Cordyceps does support alertness through cellular energy pathways. Taking it after 2 PM isn't recommended — not because it'll cause insomnia, but because its energy-support benefits align with daytime metabolic demands. Stick to the morning dose.

What's the difference between R² and ageLOC Youth (Y-Span)?
R² focuses specifically on cellular energy (Day) and detoxification (Night). Youth (Y-Span) is a broader anti-aging supplement targeting gene expression across multiple aging pathways — including antioxidant defense, cellular communication, and tissue renewal. They work through different mechanisms and can be used together. R² is the better starting point if energy is your primary concern; Y-Span if you want comprehensive anti-aging support.

Works With

ageLOC Youth (Y-Span): Where R² targets cellular energy and purification, Y-Span addresses broader gene expression patterns associated with aging. Together they form Nu Skin's most comprehensive internal anti-aging protocol. There's minimal ingredient overlap — they work through different pathways.

LifePak or LifePak Nano: R² isn't a multivitamin. It doesn't contain the essential vitamins, minerals, and omega-3s your body needs as a nutritional foundation. Pairing R² with LifePak ensures you're covering basic nutritional gaps while R² handles the cellular energy optimization. Think of LifePak as the foundation, R² as the targeted upgrade.

Beauty Focus Collagen+: Cellular energy production directly affects skin health — your skin cells need ATP to produce collagen and repair UV damage. Supporting energy production (R²) while supplementing collagen peptides (Collagen+) addresses skin aging from two angles.

Important Information

FDA Notice: *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Consult your healthcare provider before use if you are pregnant, nursing, taking medication, or have a medical condition. Keep out of reach of children. Do not exceed the recommended daily intake.

Affiliate Disclosure: NuBest Skin is an Independent Nu Skin Brand Affiliate. This website is independently operated and is not produced, endorsed, supported, or affiliated with Nu Skin Enterprises, Inc. All product names, logos, and brands are property of their respective owners.

Sources & References

1. Chen S, et al. "Effect of Cs-4 on exercise performance." Journal of Alternative and Complementary Medicine, 2010. PMID: 20804368.
2. Ryu D, et al. "Urolithin A induces mitophagy and prolongs lifespan." Nature Medicine, 2016. PMID: 28218021.
3. Saller R, et al. "An updated systematic review of milk thistle." Phytotherapy Research, 2020. Meta-analysis of 16 clinical trials on silymarin hepatoprotection.
4. Egner PA, et al. "Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage." Cancer Prevention Research, 2014. PMID: 24913818.
5. Nu Skin Enterprises, Inc. — ageLOC R² product documentation and gene expression research data.

Reviewed by the NuBest Skin Editorial Team. Last updated: April 2026.