ageLOC® R2 Night + Day (USA)

For the American Who's Tired of Being Tired — and Done Stacking Supplements

You're already doing everything right: 8-hour sleep target, morning workout, meal prep on Sundays. But by 3 PM in your office — the AC running full blast, third coffee wearing off — your focus drops off a cliff. If that sounds familiar, the issue may not be your habits. It may be cellular. ageLOC® R2 Night + Day is a 30-day, two-formula supplement system that splits its ingredients across your circadian rhythm: one formula supporting mitochondrial energy production during the day, another supporting your body's natural cellular detoxification process overnight. At $118.00 for the complete kit, it's designed for adults who've outgrown single-serving multivitamins and want a supplement that works with the body's own 24-hour cycle — not against it.

Best suited for: Adults 30+ experiencing gradual afternoon energy decline, those already taking multiple supplements who want a consolidated circadian approach, anyone focused on long-term cellular health rather than immediate stimulant effects.

Less suited for: Anyone seeking an immediate energy boost or stimulant effect; those looking for a single-capsule-once-a-day solution.

Pairs well with: ageLOC® Youth Anti-Aging Supplement, Lifepak® Nano Anti-Aging Multivitamin, Nano CoQ10

What Makes ageLOC® R2 Night + Day Different

The foundational insight behind R2 is straightforward but rarely acted on in supplement formulation: your body has fundamentally different needs at 8 AM than it does at 10 PM. During waking hours, you need efficient mitochondrial energy production — the cellular process by which your body converts nutrients into ATP, the fuel that powers every biological function. At night, your cells need to clear accumulated metabolic waste and support repair processes. Most supplements ignore this distinction entirely, delivering every active ingredient in one morning serving and leaving your body to figure out the timing.

R2 splits its formula into two distinct, circadian-aligned products:

• R2 Day — taken with breakfast, supporting mitochondrial efficiency and cellular energy output through active hours
• R2 Night — taken before bed, supporting the body's natural detoxification pathways and cellular purification during sleep

This architecture is grounded in Nu Skin's gene expression research into age-related cellular decline — specifically the pathways governing mitochondrial function and endogenous detoxification enzyme activity. Rather than adding stimulants to paper over fatigue, R2 targets the underlying cellular mechanisms.

One honest note: R2 is not a stimulant. There is no caffeine buzz 30 minutes after your first capsule. The effects accumulate over 2–4 weeks of consistent use and tend to present as sustained energy through the afternoon rather than a spike-and-crash pattern. If you want immediate effects, this product is not the right fit.

Key Ingredients

R2 Day Formula

• Cordyceps sinensis Cs-4 (standardized cultured strain) — Used for centuries in traditional Chinese medicine, Cordyceps Cs-4 is a laboratory-cultured strain with documented effects on cellular energy metabolism. A randomized controlled trial published in the Journal of Alternative and Complementary Medicine (2010, PMID: 20804368) demonstrated improved aerobic capacity and endurance in healthy adults after 3 weeks of supplementation. Crucially, the mechanism is mitochondrial — not stimulant-based.
• Pomegranate extract (punicalagins, ellagic acid) — Supports mitochondrial biogenesis, the body's process of generating new mitochondria. A landmark 2016 study in Nature Medicine (PMID: 28218021) identified urolithin A — a metabolite produced from pomegranate compounds — as a mitochondrial renewal activator in human cells.
• Chokeberry (Aronia) extract — Among the highest-ORAC-value berries available, providing concentrated anthocyanin antioxidants that help protect mitochondrial membranes from the oxidative stress that naturally occurs during energy production.

R2 Night Formula

• Milk thistle extract (silymarin) — The most extensively studied liver-support compound in supplement science. A 2020 meta-analysis in Phytotherapy Research reviewed 16 clinical trials confirming its hepatoprotective properties. Silymarin supports both Phase I and Phase II liver detoxification pathways — the enzymatic systems responsible for processing and clearing metabolic waste.
• Broccoli seed extract (glucoraphanin → sulforaphane precursor) — Glucoraphanin converts to sulforaphane in the body, which activates the Nrf2 pathway — often described as the body's master switch for antioxidant defense enzymes. Research published in Cancer Prevention Research (2014, PMID: 24913818) demonstrated sulforaphane's role in enhancing detoxification of airborne pollutants by 61% in a clinical setting.

How to Use

Take 2 R2 Day capsules with breakfast each morning. Take 2 R2 Night capsules approximately 30 minutes before bed. Do not take the Day capsules in the evening — Cordyceps may support alertness and could interfere with sleep onset. Do not skip the Night capsules; the cellular purification cycle depends on nightly consistency.

Most users begin to notice changes in sustained afternoon energy within 7–14 days. The full cellular renewal benefit builds over 30–90 days of consistent daily use.

How ageLOC® R2 Compares

Feature	ageLOC® R2 Night + Day	Thorne ResveraCel	Garden of Life Vitamin Code Raw Energy	Nature Made Multi for Him/Her
Dosing architecture	Circadian-split: Day formula (energy) + Night formula (detox purification)	Single-formula NAD+ precursor + resveratrol, once daily	Single whole-food multi + green tea, once daily	Single multivitamin tablet, once daily
Mitochondrial energy support	Cordyceps Cs-4 (standardized cultured strain, ATP pathway support)	Nicotinamide riboside (NAD+ coenzyme precursor)	Green tea extract, B-vitamins via raw whole foods	B-vitamin complex (standard forms)
Cellular detoxification support	Silymarin (milk thistle) + glucoraphanin (broccoli seed, Nrf2 activation)	Quercetin (antioxidant support only)	Raw organic sprouts blend	Not included
Antioxidant protection	Pomegranate (punicalagins, ellagic acid) + Aronia (anthocyanins)	Resveratrol (trans-resveratrol 20mg)	Fruit/veggie blend (whole food forms)	Vitamins C and E (standard synthetic)
Circadian alignment	Yes — active ingredients timed to biological need	No — single daily dose	No — single daily dose	No — single daily dose
Stimulant-free	Yes	Yes	Contains green tea (natural caffeine)	Yes
Available at	nubestskin.com/us	Amazon, Thorne.com, practitioner dispensaries	Whole Foods, Amazon, iHerb	CVS, Walmart, Target

Table note: Differences in dosing architecture and specific ingredient forms reflect distinct formulation philosophies. Ingredient bioavailability and pathway targeting vary significantly across these approaches.

Frequently Asked Questions

Where can I buy ageLOC® R2 Night + Day in the US, and how long does shipping take?

ageLOC® R2 Night + Day ($118.00) is available at nubestskin.com/us. Orders ship from the official Nu Skin US warehouse, typically arriving within 3–5 business days across the continental United States. Alaska and Hawaii may require additional transit time.

What does the "$118.00" kit actually include?

The $118.00 price covers a 30-day supply of both the R2 Day formula and the R2 Night formula — the complete two-bottle system. You do not need to purchase them separately to complete the full protocol.

Will I feel an energy boost on the first day?

No — and that's by design. ageLOC® R2 does not contain stimulants like caffeine or guarana. Effects are cellular and accumulative, typically beginning to show as reduced afternoon fatigue within 7–14 days of daily use. Full benefits build over a 30–90 day consistent regimen.

Can I take R2 alongside other Nu Skin supplements like Lifepak® Nano?

Yes. R2's Day and Night formulas target mitochondrial efficiency and cellular detoxification pathways, which are complementary to the broad-spectrum micronutrient support in Lifepak® Nano. As always, consult your healthcare provider before combining supplements, especially if you take prescription medications.

Why shouldn't I take the R2 Day capsules at night?

The R2 Day formula contains Cordyceps Cs-4, which supports cellular alertness and oxygen utilization. Taking it in the evening may interfere with sleep onset for sensitive individuals. Keep Day capsules strictly to breakfast time and Night capsules to your pre-sleep routine.

Is ageLOC® R2 regulated or tested for quality in the US?

Nu Skin's Pharmanex supplement division operates under cGMP (current Good Manufacturing Practice) guidelines consistent with FDA dietary supplement regulations (21 CFR Part 111). As with all dietary supplements sold in the US, these products are regulated by the FDA as dietary supplements, not drugs. See the FDA disclaimer below.

How does R2 differ from the standalone R2 Day or R2 Night products sold separately?

The ageLOC® R2 Night + Day kit bundles both the R2 Day and R2 Night formulas together at $118.00. Purchasing them separately — Day at $59.00 and Night at $65.00 — totals $124.00. The bundled kit is the most practical option for those committing to the full circadian protocol.

Is this product suitable for vegetarians or people with dietary restrictions?

For detailed allergen, capsule composition, and dietary suitability information, refer to the product label or contact Nu Skin US customer support directly. Ingredient lists on the current US product packaging are the authoritative reference for allergen status.

Works Well With

• Lifepak® Nano Anti-Aging Multivitamin — broad-spectrum micronutrient foundation to complement R2's targeted cellular approach
• Nano CoQ10 — nanotechnology-delivered CoQ10 for additional mitochondrial membrane support
• ageLOC® Youth Anti-Aging Supplement — targets gene expression pathways associated with cellular aging alongside R2's energy and purification protocol
• CordyMax Cs-4® — standalone Cordyceps Cs-4 supplement for those who want to amplify the Day formula's mitochondrial support
• Tegreen 97® — concentrated green tea polyphenols (EGCG) for complementary antioxidant defense
• ageLOC® R2 Day (individual) — for restocking Day capsules only
• ageLOC® R2 Night (individual) — for restocking Night capsules only

Sources & References

• Chen, S. et al. (2010). Randomized double-blind placebo-controlled trial of Cordyceps sinensis Cs-4 in healthy adults. Journal of Alternative and Complementary Medicine. PMID: 20804368. https://pubmed.ncbi.nlm.nih.gov/20804368/
• Ryu, D. et al. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature Medicine. PMID: 28218021. https://pubmed.ncbi.nlm.nih.gov/28218021/
• Gillessen, A. & Schmidt, H.H. (2020). Silymarin as supportive treatment in liver diseases: a narrative review. Advances in Therapy. https://pubmed.ncbi.nlm.nih.gov/32705502/
• Egner, P.A. et al. (2014). Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial. Cancer Prevention Research. PMID: 24913818. https://pubmed.ncbi.nlm.nih.gov/24913818/
• Nu Skin Enterprises — ageLOC R2 product information: nuskin.com

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*Independent Nu Skin Brand Affiliate — not produced or endorsed by Nu Skin Enterprises Inc.*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.*