ageLOC® R2 Day (Vitality) (USA)

ageLOC R² Day is the daytime half of Nu Skin's R² cellular energy system, sold here as a standalone product. It targets mitochondrial energy production using Cordyceps Cs-4, pomegranate extract, and chokeberry — supporting your cells' ability to generate ATP (the energy currency every cell runs on) without relying on stimulants like caffeine. At US$59.00 for a 30-day supply, this listing is primarily for customers restocking R² Day separately, or for anyone wanting to try the daytime energy formula before committing to the full R² Night + Day kit (US$118.00).

What Makes R² Day Different

Most "energy supplements" on the US market work through stimulation — caffeine, guarana, B-vitamin megadoses that make your nervous system run hotter. R² Day works at the mitochondrial level, supporting the actual cellular machinery that converts nutrients into ATP. A 2010 randomized controlled trial published in the Journal of Alternative and Complementary Medicine (PMID: 20804368) confirmed that Cordyceps Cs-4 improved aerobic capacity and oxygen utilization in healthy adults after 3 weeks. The difference in how the energy feels is notable: no jitters, no crash, just more consistent capacity throughout the day.

R² Day is designed to pair with R² Night (cellular purification), but it functions independently. On its own, it provides daytime cellular energy support without the overnight detoxification component. If energy is your primary concern and budget matters, Day alone is a reasonable starting point — you can add Night later if you want the full 24-hour protocol.

Key Ingredients

Cordyceps sinensis Cs-4 — standardized cultured cordyceps strain that supports mitochondrial ATP production and oxygen utilization. Documented in multiple clinical trials for cellular energy enhancement without stimulant effects.

Pomegranate extract — contains punicalagins that metabolize into urolithin A, identified in Nature Medicine (2016, PMID: 28218021) as a mitochondrial renewal activator that triggers mitophagy (recycling of damaged mitochondria).

Chokeberry (Aronia) extract — high-ORAC anthocyanin antioxidant that protects mitochondrial membranes from oxidative damage during energy production.

How to Use

Take 2 capsules with breakfast each morning. Don't take in the evening — Cordyceps supports alertness through cellular energy pathways and is best aligned with daytime metabolic demands. Results typically become noticeable within 7-14 days as sustained afternoon energy, with full effects building over 30-90 days. Pair with the full R² Night + Day kit for the complete circadian protocol.

Who Is This For

Ideal for: Adults experiencing afternoon energy dips who want cellular-level support without stimulants. Also for customers restocking the Day component separately.

Also suited for: Anyone curious about R² who wants to test the daytime formula before investing in the full kit.

Not recommended for: Anyone under 25 with naturally efficient cellular energy production — you likely won't notice a difference at this age.

Frequently Asked Questions

Can I buy R² Day in the US without signing up?
Yes. No membership, no registration. NuBest Skin ships from the official US Nu Skin warehouse.

Do I need R² Night as well?
R² Day works independently for daytime energy support. The full R² system (Day + Night) provides 24-hour cellular support — energy production during the day, purification overnight. If budget allows, the combined kit at US$118.00 is better value than buying both separately.

Is this a stimulant?
No. R² Day contains no caffeine or CNS stimulants. It supports energy at the mitochondrial level — a different mechanism entirely. No jitters, no crashes, no sleep disruption.

Important Information

FDA Notice: *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Consult your healthcare provider before use if you are pregnant, nursing, taking medication, or have a medical condition. Keep out of reach of children.

Affiliate Disclosure: NuBest Skin is an Independent Nu Skin Brand Affiliate. This website is independently operated and is not produced, endorsed, supported, or affiliated with Nu Skin Enterprises, Inc. All product names, logos, and brands are property of their respective owners.

Sources & References

1. Chen S, et al. "Effect of Cs-4 on exercise performance." Journal of Alternative and Complementary Medicine, 2010. PMID: 20804368.
2. Ryu D, et al. "Urolithin A induces mitophagy." Nature Medicine, 2016. PMID: 28218021.
3. Nu Skin Enterprises, Inc. — ageLOC R² product documentation.

Reviewed by the NuBest Skin Editorial Team. Last updated: April 2026.