ageLOC TRMe® 90-Day Kit with Nu Biome®

The Weight Management Program That Works the Gut-Metabolism Angle

You've committed to a structured 90-day weight management protocol — but if you've ever noticed that your digestion goes sideways whenever you overhaul your diet, you're not imagining it. Research published in Nature Reviews Endocrinology (PMID: 30670819) confirms that gut microbiome composition directly influences metabolic function, appetite signaling, and nutrient processing efficiency. The ageLOC TRMe® 90-Day Kit with Nu Biome® ($1,369.23) is built for the American who's done the 30-day trial, decided to go all-in on a full season of change, and wants gut-metabolic support running in parallel from day one.

This is Nu Skin's most gut-inclusive weight management bundle available in the US — four core TRMe products covering appetite, metabolism, mood/cravings, and protein intake, layered with 90 days of Nu Biome prebiotic and postbiotic support.

Best suited for: TRMe users ready to commit to a full 90-day program who also want gut microbiome support during the dietary transition — particularly relevant if you've experienced digestive disruption during previous diet changes.

Less suited for: First-time TRMe users — start with the ageLOC TRMe 30-Day Kit ($460.77) to confirm the protocol works for your routine before committing to 90 days.

Pairs well with: Marine Omega ($53.90) for additional metabolic and cardiovascular support; ageLOC® R2 Night + Day ($118.00) for cellular energy optimization alongside the weight management program.

What's Inside the Kit

This bundle includes three months of each of the following — one for each month of the 90-day protocol:

ageLOC TRMe Slim-S (3 boxes)

Appetite and fat-management capsules featuring Bupleurum root and citrus extracts. Taken as two capsules before each main meal, three times daily (6 capsules per day). 90 capsules per box.

ageLOC TRMe SmartWin (3 boxes)

Metabolic-rate support formulated with green tea extract (EGCG) and capsicum. Contains caffeine from natural sources. One capsule with breakfast, one with lunch. 60 capsules per box.

ageLOC TRMe MyTriumph (3 boxes)

Mood and cravings support with saffron extract and L-theanine for calm focus. One capsule twice daily. 60 capsules per box.

ageLOC TRMe Protein (3 boxes)

Plant-based protein shake delivering 15g of protein per serving for meal replacement nutrition. 15 sachets per box.

ageLOC Nu Biome® (3 boxes)

Pre- and postbiotic powder in convenient stick packs. One sachet daily mixed into cold water. FOS (fructooligosaccharides) and XOS (xylooligosaccharides) prebiotic fibers support beneficial gut bacteria populations, while postbiotic metabolites support gut barrier integrity and metabolic signaling. 30 sachets per box.

What Makes the TRMe + Nu Biome Combination Different

The TRMe system is already a multi-pillar weight management protocol — most Americans shopping in this category are used to seeing single-ingredient supplements promising dramatic results. What TRMe does differently is address four distinct variables simultaneously: appetite (Slim-S), metabolic rate (SmartWin), emotional eating and cravings (MyTriumph), and nutritional protein intake (Protein shake).

The Nu Biome layer adds a fifth dimension: the gut-metabolic axis. When you reduce caloric intake and shift dietary patterns — exactly what the TRMe protocol involves — your gut microbiome composition responds to that change. Research in Nature Reviews Endocrinology (PMID: 30670819) documented how specific microbial metabolites directly regulate host metabolic pathways. The FOS and XOS prebiotic fibers in Nu Biome help sustain beneficial bacterial populations through this transition, while the postbiotic compounds support gut barrier function and downstream metabolic signaling.

In practical terms: this combination is designed for the person doing a structured dietary overhaul who wants metabolic support working from both directions — the supplement protocol and the gut environment it operates within.

How It Compares

Product	Formulation Approach	Gut Support	Mood/Craving Support	Protein Component	Program Length
ageLOC TRMe 90-Day Kit + Nu Biome	4-pillar system: appetite, metabolism, mood/cravings, protein + pre/postbiotic gut layer	FOS + XOS prebiotics + postbiotic metabolites (Nu Biome)	Saffron extract + L-theanine (MyTriumph)	15g plant protein per serve (TRMe Protein)	90 days structured
Thorne Metabolic Health Bundle	Practitioner-grade single-target metabolic supplements (berberine, chromium); no integrated program structure	No dedicated gut support product in standard bundle	No dedicated mood/craving formulation	Separate purchase required	No defined program timeline
Garden of Life FitRaw Program	Organic whole-food protein + probiotic supplements; plant-first formulation	Probiotic (CFU-based) — live cultures, no structured prebiotic + postbiotic combination	No dedicated mood/craving formulation	22g organic plant protein; strong protein pillar, weaker metabolic pillars	No defined 90-day protocol
Nature Made Weight Management Bundle	Mass-market single-ingredient supplements (CLA, green tea extract); USP verified for basic purity	No gut microbiome support	No dedicated mood/craving formulation	No protein component	No structured program

Comparison reflects formulation structure and ingredient category coverage. Individual results vary.

How to Use

Follow the standard TRMe daily protocol:

• Slim-S: Two capsules before each main meal, three times daily
• SmartWin: One capsule with breakfast, one capsule with lunch
• MyTriumph: One capsule twice daily
• TRMe Protein: One sachet per day as a meal replacement shake
• Nu Biome: One stick pack mixed into cold water daily — morning or evening works equally well

Note on Nu Biome startup: The prebiotic fibers (FOS and XOS) may cause mild bloating during the first few days as your gut microbiome adjusts. This is a normal prebiotic response and typically resolves within 3–5 days as beneficial bacteria populations adapt.

Important: SmartWin contains caffeine from natural sources. Consult your healthcare provider before beginning this or any weight management program. Not intended for use by pregnant or nursing women, or individuals under 18. Keep out of reach of children.

Frequently Asked Questions

Does this ship to all US states, and how long does delivery take?

Yes — the ageLOC TRMe 90-Day Kit with Nu Biome ships from the official Nu Skin US warehouse. Delivery typically takes 3–5 business days across the continental United States. Alaska and Hawaii may require additional transit time. No membership or subscription is required to purchase.

Is Nu Biome required for the TRMe system to work?

No. The TRMe system is a complete, standalone weight management protocol. Nu Biome adds pre- and postbiotic gut-metabolic support, which may be particularly beneficial during the dietary transition that accompanies any structured weight management program. It's an enhancement, not a dependency.

Why commit to 90 days instead of the 30-day kit?

Meaningful body composition changes — and shifts in gut microbiome diversity — take time. A 90-day commitment allows the full TRMe protocol and Nu Biome's gut support to work across multiple biological adaptation cycles. The 30-Day Kit ($460.77) exists specifically so first-time users can confirm the protocol suits their lifestyle before making a longer commitment.

Can I take Nu Biome on its own if I already have the standard TRMe 90-Day Kit?

Yes — Nu Biome Gut Health Formula ($51.00) is available separately on the US store. If you've already purchased the standard TRMe 90-Day Kit and want to add gut support, Nu Biome can be added independently.

Does this kit contain caffeine?

Yes. The SmartWin component contains caffeine from natural sources (green tea extract and guarana). If you're sensitive to caffeine or take medications that interact with stimulants, consult your healthcare provider before use. Nu Biome and the other TRMe components do not contain caffeine.

How is this different from the ageLOC TRMe & R² 90-Day Kit?

The ageLOC TRMe & R² 90-Day Kit ($1,446.15) pairs TRMe with the ageLOC R2 cellular energy system, which focuses on mitochondrial optimization and cellular renewal. This bundle instead pairs TRMe with Nu Biome's gut-metabolic axis support. Both expand on the core TRMe protocol — the right choice depends on whether your priority is gut microbiome support or cellular energy optimization.

What prebiotic fibers does Nu Biome use, and why do they matter for weight management?

Nu Biome uses FOS (fructooligosaccharides) and XOS (xylooligosaccharides) — two well-studied prebiotic fiber types that selectively feed beneficial gut bacteria including Bifidobacterium species. During a calorie-restricted diet, the gut microbial environment shifts; these fibers help sustain populations of bacteria associated with healthy metabolic signaling. The postbiotic metabolites in Nu Biome support gut barrier integrity, which is relevant to how nutrients and metabolic signals are processed during a weight management program.

Works With

• Nu Biome® Gut Health Formula ($51.00) — available separately to extend gut support after the 90-day kit concludes
• ageLOC TRMe 30-Day Kit ($460.77) — ideal starting point for first-time TRMe users before committing to 90 days
• TRMe™ GO Protein+ ($55.00) — additional plant-based protein support for active users integrating exercise into the program
• TRMe™ GO PreWorkout+ ($48.00) — pre-exercise energy support designed to complement the TRMe system
• TRMe™ GO Recovery+ ($48.00) — post-workout recovery support for users incorporating fitness routines
• Marine Omega ($53.90) — omega-3 fatty acid support for metabolic and cardiovascular health during the program
• Probio PCC™ Live Probiotics ($35.90) — live culture probiotic support to complement Nu Biome's prebiotic and postbiotic formula

Sources & References

1. Fan Y, Pedersen O. "Gut microbiota in human metabolic health and disease." Nature Reviews Endocrinology, 2021. PMID: 30670819.
2. Nu Skin Enterprises, Inc. — ageLOC TRMe and Nu Biome US product documentation. nuskin.com

Reviewed by the NuBest Skin Editorial Team. Last updated: May 2026.

*Independent Nu Skin Brand Affiliate — not produced or endorsed by Nu Skin Enterprises Inc.*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.*