ageLOC® R2 Night (USA)

The Supplement Houston and LA Air Quality Reports Inspired You to Actually Research

You've checked the AQI app in Houston on a summer afternoon. You've sat in LA traffic with the windows down, or made it through another NYC rush hour crammed into the subway. Your body processes that low-grade environmental load constantly — but the heaviest cellular clearing work happens at night, when your liver's detoxification machinery runs at peak activity. ageLOC® R² Night ($65.00) is formulated specifically for that overnight biological window, delivering three evidence-backed compounds — milk thistle extract (silymarin), broccoli seed extract (a sulforaphane precursor), and curcumin — timed to support the purification and cellular repair processes most active during sleep. This is the standalone evening component of Nu Skin's R² system, available separately for those restocking Night independently or exploring the purification formula before committing to the full 24-hour protocol.

Best suited for: Urban residents in high-pollution metros (Houston, Los Angeles, New York, Phoenix) with regular environmental particulate exposure; adults who consume alcohol moderately and want to support consistent liver function; anyone over 35 wanting to address cellular detoxification as part of a structured nightly supplement routine; existing R² Day users completing the full 24-hour system.

Less suited for: Anyone expecting an acute "cleanse" or short-term hangover remedy — R² Night supports ongoing biochemical pathways, not immediate recovery. Not intended as a sleep aid — it does not contain melatonin or sedative ingredients. Those with existing liver conditions should consult a physician before use.

Pairs well with: ageLOC® R² Day ($59.00) for the complete circadian energy + purification protocol; Beauty Focus™ Collagen+ ($87.00) for a comprehensive inside-out wellness routine; Tegreen 97® ($63.00) for additional antioxidant support.

What Makes R² Night Different

Most "detox" supplements sold at Whole Foods or on Amazon are strategically vague — "supports cleansing" or "promotes renewal" without specifying which biochemical pathway they're addressing or at what concentration. R² Night is formulated around specific, well-researched mechanisms rather than marketing language.

Milk Thistle Extract (Silymarin)

Silymarin is the most extensively studied liver-support compound in supplement science, with research spanning more than 200 clinical trials. A 2020 meta-analysis published in Phytotherapy Research confirmed its hepatoprotective properties across 16 randomized controlled trials. R² Night uses milk thistle extract targeting the silymarin flavonolignans responsible for supporting both Phase I and Phase II liver detoxification pathways — the two-stage enzymatic process your liver uses to neutralize and eliminate environmental compounds.

Broccoli Seed Extract (Glucoraphanin → Sulforaphane)

Broccoli seed extract provides concentrated glucoraphanin, which your body enzymatically converts to sulforaphane — a compound that activates the Nrf2 pathway, effectively switching on your body's endogenous antioxidant defense network. Research published in Cancer Prevention Research (2014, PMID: 24913818) demonstrated that sulforaphane-rich broccoli sprout beverage enhanced detoxification of airborne pollutants by 61% — a finding with direct relevance for anyone regularly breathing the air in Los Angeles, Houston, or Chicago.

Curcumin

Curcumin from turmeric supports NF-kB pathway regulation — a cellular signaling pathway involved in the inflammatory response — and contributes to the antioxidant environment that enables efficient cellular repair processes. Taken nightly, it works alongside the silymarin and sulforaphane precursor to support the body's natural overnight recovery activity.

How R² Night Compares

Product	Key Detox Compounds	Silymarin Form	Sulforaphane Pathway	Curcumin	Circadian Timing Design
ageLOC® R² Night	Milk thistle, broccoli seed extract, curcumin	Standardized silymarin extract	Glucoraphanin precursor (enzymatic conversion)	✓ Included	Yes — formulated as part of a 24-hour Day/Night system
Thorne Liver Cleanse	Milk thistle, artichoke, dandelion	Silymarin-standardized extract	Not included	✗ Not included	No — single-function liver formula, no circadian pairing
Garden of Life Liver Detox	Milk thistle blend, organic herbs	Whole herb / blend (standardization not disclosed)	Not included	✗ Not included	No — general wellness positioning
NOW Foods Liver Refresh	Milk thistle, N-acetyl cysteine, turmeric	80% silymarin standardized	Not included	Turmeric (not isolated curcumin)	No — standalone formula

Comparison based on publicly available ingredient disclosures as of 2024. Formulations subject to change by respective manufacturers.

How to Use

Take 2 capsules 30 minutes before bed. R² Night does not contain melatonin or sedative ingredients — it is timed for evening use because your body's natural detoxification and cellular repair processes are most active during sleep, not because the product induces drowsiness. Consistent nightly use over 30 or more days allows detoxification-support compounds to work cumulatively. For the full R² protocol, pair with ageLOC® R² Day ($59.00) each morning.

Frequently Asked Questions

Does ageLOC® R² Night ship to the continental US, and how long will it take?

Yes. NuBest Skin ships ageLOC® R² Night from the official Nu Skin US warehouse. Delivery across the continental US typically takes 3–5 business days. Alaska and Hawaii orders may require additional transit time. No membership or sign-up is required to purchase.

Will R² Night make me drowsy or help me sleep?

No. R² Night does not contain melatonin, valerian, magnesium glycinate, or any other sleep-inducing compound. It is taken before bed because cellular detoxification enzyme activity peaks during sleep — the formula supports that process, but does not cause drowsiness. If you're also looking for sleep support, that would require a separate supplement.

Can I take R² Night without R² Day?

Yes. The Night formula has independent value for cellular purification and detoxification support and does not require R² Day to function. However, the full R² system — Day for cellular energy support, Night for overnight purification — is designed as a complementary 24-hour protocol. If you want both, the ageLOC® R² Night + Day bundle ($118.00) is available.

Who might especially benefit from R² Night?

R² Night is particularly relevant for adults with regular environmental pollutant exposure (urban residents in high-AQI metros like LA, Houston, or Phoenix), those who consume alcohol moderately, or anyone over 35 looking to actively support the liver's detoxification processing capacity as part of a structured supplement routine. It addresses specific biochemical pathways rather than making generalized "cleanse" claims.

Is this product FDA-approved?

Dietary supplements are not FDA-approved in the same way pharmaceutical drugs are. R² Night is manufactured in accordance with FDA dietary supplement regulations (21 CFR Part 111), which govern Good Manufacturing Practice (GMP) standards for supplement production. The statements about this product have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Can I take R² Night if I'm on medication or have a liver condition?

Consult your physician or pharmacist before use if you are taking prescription medications, are pregnant or nursing, or have a diagnosed liver condition. Milk thistle can interact with certain medications metabolized by cytochrome P450 enzymes. A healthcare provider familiar with your full medication profile is the appropriate person to advise on compatibility.

What is the difference between this listing and the R² Night + Day bundle?

This listing ($65.00) is for R² Night only — the evening component. It's designed for customers who are restocking Night separately (while still having Day capsules remaining) or who want to try the purification formula independently. The ageLOC® R² Night + Day bundle ($118.00) includes both the morning and evening formulas for the complete 24-hour protocol.

Works With — Build Your Protocol

• ageLOC® R² Day (Vitality) ($59.00) — the morning cellular energy counterpart. Together with R² Night, completes the full 24-hour R² purification and vitality system.
• ageLOC® R² Night + Day ($118.00) — the bundled Day + Night system for the complete circadian protocol.
• Beauty Focus™ Collagen+ Peach ($87.00) — ingestible collagen support to complement a cellular health regimen from the inside out.
• Tegreen 97® ($63.00) — standardized green tea catechin antioxidant supplement for additional free-radical defense support.
• Nu Biome® Gut Health Formula ($51.00) — gut microbiome support that pairs naturally with a detoxification-focused supplement routine.
• Marine Omega ($53.90) — omega-3 fatty acid support for a comprehensive daily wellness stack.

Sources & References

1. Saller R, et al. "An updated systematic review of milk thistle (Silybum marianum)." Phytotherapy Research, 2020. PubMed: 32285538
2. Egner PA, et al. "Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage." Cancer Prevention Research, 2014. PMID: 24913818
3. Fahey JW, et al. "Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors." Proceedings of the National Academy of Sciences, 2002. PMID: 11960991
4. Nu Skin Enterprises — ageLOC® R² product information. nuskin.com

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*Independent Nu Skin Brand Affiliate — not produced or endorsed by Nu Skin Enterprises Inc.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.