ageLOC® R2 Night (USA)

ageLOC R² Night is the evening component of Nu Skin's R² system, focusing on overnight cellular purification and detoxification. While you sleep, your body's repair and waste-clearing processes are most active — R² Night supports these with milk thistle (the most-studied liver-support compound in supplement science), broccoli seed extract (a sulforaphane precursor that activates detoxification enzymes), and curcumin. At US$65.00 for a 30-day supply, this listing is for customers restocking Night separately or trying the purification formula independently before committing to the full R² kit.

What Makes R² Night Different

Most "detox" supplements on the market are vague about what they actually do — "cleanse your body" with mystery blends. R² Night targets specific, well-researched biochemical pathways. Milk thistle (silymarin) has been studied in over 200 clinical trials for liver protection and detoxification support. A 2020 meta-analysis in Phytotherapy Research confirmed its hepatoprotective properties across 16 randomized controlled trials. Broccoli seed extract provides glucoraphanin, which your body converts to sulforaphane — a compound that activates the Nrf2 pathway, essentially turning on your body's built-in antioxidant defense system.

R² Night complements R² Day (cellular energy) for the full 24-hour protocol, but it has genuine standalone value for anyone focused specifically on detoxification support. If you live in a high-pollution city (LA, Houston, NYC), drink alcohol regularly, or simply want to support your liver's processing capacity, R² Night addresses that directly.

Key Ingredients

Milk thistle extract (silymarin) — hepatoprotective compound confirmed in meta-analyses across 16+ clinical trials. Supports Phase I and Phase II liver detoxification pathways.

Broccoli seed extract — concentrated glucoraphanin source that converts to sulforaphane. Research in Cancer Prevention Research (2014, PMID: 24913818) showed sulforaphane enhanced detoxification of airborne pollutants by 61%.

Curcumin — anti-inflammatory and antioxidant compound from turmeric. Supports NF-kB pathway regulation and cellular repair processes active during sleep.

How to Use

Take 2 capsules 30 minutes before bed. R² Night doesn't contain sleep-inducing ingredients like melatonin — it's taken before bed because the body's natural detoxification processes are most active during sleep, not because the product causes drowsiness. Consistent nightly use for 30+ days provides the best results as detoxification support compounds over time.

Who Is This For

Ideal for: Anyone wanting targeted liver and cellular detoxification support — particularly relevant for urban dwellers, moderate alcohol consumers, or those exposed to environmental pollutants regularly.

Also suited for: Customers restocking R² Night separately while still having R² Day capsules remaining.

Not recommended for: Anyone expecting it to induce sleep — R² Night supports overnight cellular processes but isn't a sleep aid.

Frequently Asked Questions

Can I buy R² Night in the US without signing up?
Yes. No membership needed. NuBest Skin ships from the official US warehouse.

Will this make me drowsy?
No. R² Night doesn't contain melatonin or sedative ingredients. It's taken before bed because detoxification processes are most active during sleep — not because the product induces sleep.

Can I take R² Night without R² Day?
Yes. The Night formula works independently for cellular purification support. For the full R² protocol (energy + purification), add R² Day to your morning routine.

Important Information

FDA Notice: *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Consult your healthcare provider before use if you are pregnant, nursing, taking medication, or have a medical condition. Keep out of reach of children.

Affiliate Disclosure: NuBest Skin is an Independent Nu Skin Brand Affiliate. This website is independently operated and is not produced, endorsed, supported, or affiliated with Nu Skin Enterprises, Inc. All product names, logos, and brands are property of their respective owners.

Sources & References

1. Saller R, et al. "An updated systematic review of milk thistle." Phytotherapy Research, 2020.
2. Egner PA, et al. "Detoxication of airborne pollutants by broccoli sprout beverage." Cancer Prevention Research, 2014. PMID: 24913818.
3. Nu Skin Enterprises, Inc. — ageLOC R² Night product documentation.

Reviewed by the NuBest Skin Editorial Team. Last updated: April 2026.