ageLOC® R² (R2) Night (Ireland/EU)

Overnight Cellular Purification — Built for the Irish Urban Commuter

You've done the Dublin commute — diesel fumes on the quays, underground car parks, heated office air recycled all day. By the time you're home, your body has been processing airborne pollutants for twelve-plus hours. ageLOC R² Night is a food supplement formulated specifically to support the cellular purification processes that intensify while you sleep: milk thistle (silymarin), broccoli seed extract (a sulforaphane precursor activating the Nrf2 detoxification pathway), and curcumin. Two capsules before bed. No sedating ingredients. No disrupted sleep. Just targeted overnight support for the body's own clean-up mechanisms. At €59.00 per month, it is designed to be taken as a consistent daily supplement over 30+ days, either standalone or as the Night component of the ageLOC R² Day + Night system.

Best suited for: Adults in urban environments (Dublin, Cork, Galway commuters) with daily exposure to traffic pollution, indoor heating, and air quality stress; anyone seeking to support liver and cellular detoxification through diet and supplementation; those already taking ageLOC R² Day who want the full 24-hour system.

Less suited for: Those under 18, pregnant or breastfeeding women, or anyone with existing liver conditions without prior consultation with a GP or pharmacist.

Pairs well with: ageLOC R² Day (€66.00) for the complete day/night cellular health system; Nu Skin LifePak+ (€84.00) for broader micronutrient support.

What Makes ageLOC R² Night Different

Most food supplements aimed at "detox" support rely on generic antioxidant blends with minimal mechanistic specificity. R² Night takes a different approach — each of its three active ingredients targets a distinct but complementary arm of the body's cellular maintenance system.

Milk Thistle Extract (Silymarin)

Silymarin is the collective term for the bioactive flavonolignans found in milk thistle seed (Silybum marianum). It has been investigated in over 200 clinical studies and is one of the most extensively documented botanical ingredients for supporting hepatic (liver) function. Its proposed mechanisms include support for Phase I and Phase II liver detoxification enzyme activity — the two-stage enzymatic process through which the liver processes compounds for elimination. Silymarin is standardised by concentration in quality formulations; the form used in R² Night is selected for this purpose.

Broccoli Seed Extract (Sulforaphane Precursor — Nrf2 Pathway)

Broccoli seed extract provides glucoraphanin, which is enzymatically converted to sulforaphane in the body. Sulforaphane is a potent activator of the Nrf2 (Nuclear factor erythroid 2-related factor 2) transcription pathway — sometimes called the body's "master regulator" of antioxidant and detoxification gene expression. A clinical study published in Cancer Prevention Research (PMID: 24913818) demonstrated that sulforaphane-rich broccoli sprout beverages enhanced the detoxification of airborne pollutants by 61% in a high-pollution environment. For those living and commuting in Irish cities — where diesel particulates and indoor air quality are daily realities — this pathway is directly relevant.

Curcumin

Curcumin, the principal bioactive compound from turmeric (Curcuma longa), contributes anti-inflammatory signalling support and has been studied for its role in cellular repair processes. The overnight window is when many of the body's maintenance and repair cycles are most active, making curcumin a complementary ingredient to the liver-focused and Nrf2-activating components in R² Night.

Why "Night"?

The timing is deliberate. Hepatic detoxification activity, cellular autophagy (cellular self-cleaning), and inflammatory resolution processes are upregulated during sleep. Taking R² Night 30 minutes before bed aligns supplementation with this biological window — not because the capsules are sleep-inducing (they are not), but because the body's own systems are primed for this work overnight.

How It Compares

Product	Key Detox Ingredients	Nrf2 Activation	Liver Support (Silymarin)	Night-Timed Format	Price (IE/EU)
ageLOC R² Night	Standardised milk thistle (silymarin), broccoli seed extract (glucoraphanin → sulforaphane), curcumin	✅ Sulforaphane precursor — Nrf2 pathway activator	✅ Silymarin — Phase I & II liver detoxification	✅ Formulated for 30-min pre-sleep dosing	€59.00/month
Revive Active Zest Active	Vitamin C, zinc, B-vitamins, plant extracts; general antioxidant blend	❌ No specific Nrf2-pathway ingredient	❌ No silymarin	❌ Morning sachet format	~€50–60/month
Solgar Milk Thistle (Holland & Barrett Ireland)	Silymarin extract (single ingredient)	❌ No sulforaphane or Nrf2 activator	✅ Silymarin — single-ingredient focus	❌ Not timed; general daily supplement	~€20–25/month
Boots Ireland Turmeric & Pepper Capsules	Curcumin + black pepper (piperine for bioavailability)	❌ No Nrf2 activation ingredient	❌ No silymarin	❌ Not timed to overnight cycle	~€10–15/month

Formulation note: The comparison above reflects ingredient form and mechanistic coverage differences only. Single-ingredient products provide targeted support for their specific ingredient; R² Night combines three mechanistically distinct ingredients within one overnight-timed format. "Budget alternatives cover the same function" is not a conclusion that follows from ingredient volume alone — bioavailability, standardisation, and combinatorial effect are separate considerations.

How to Use

Take 2 capsules 30 minutes before bed. R² Night contains no melatonin, no sedating herbs, and no sleep-aid ingredients. It will not cause drowsiness. The overnight timing reflects alignment with the body's natural detoxification and repair cycles, not a pharmacological sleep effect. For meaningful results, use consistently for a minimum of 30 days. Food supplements work cumulatively — short-course or sporadic use is unlikely to reflect the supplement's intended function.

Frequently Asked Questions

Is ageLOC R² Night available in Ireland and how quickly does it ship?

Yes — R² Night is available through nubestskin.com/ie and ships from the EU Nu Skin warehouse. Delivery to Ireland typically takes 3–5 business days. Because the order ships within the EU single market, there are no customs duties or import charges. Orders can be placed without any subscription or membership sign-up.

Do I need to sign up for a subscription or account to order?

No. You can purchase ageLOC R² Night as a one-time order at €59.00 without creating an account or committing to a subscription. An account is optional if you wish to manage repeat orders.

Will this make me drowsy or affect my sleep quality?

No. ageLOC R² Night contains no melatonin, valerian, passionflower, or any other sedating ingredient. The pre-bed timing is based on alignment with the body's overnight detoxification activity — not on sleep induction. Most users report no effect on sleep onset or quality.

Can I take R² Night on its own, or do I need the Day supplement too?

R² Night functions independently as a purification-focused supplement. You do not need to purchase ageLOC R² Day simultaneously. However, ageLOC R² (the combined Day + Night pack, €115.00) offers the full 24-hour cellular health system if you wish to address both the daytime energy/vitality and overnight purification dimensions.

How is the Nrf2 pathway relevant to everyday life in an Irish city?

Ireland's urban air quality — particularly diesel particulate exposure on commuter routes in Dublin and Cork — creates a daily low-level oxidative and inflammatory load on the body. The Nrf2 pathway is the body's key mechanism for upregulating antioxidant and detoxification gene expression in response to such environmental stressors. Sulforaphane, derived from glucoraphanin in broccoli seed extract, is one of the most studied natural Nrf2 activators. The clinical evidence underpinning R² Night's broccoli seed extract (PMID: 24913818) comes from a real-world pollution exposure study, not a laboratory-only model.

Is this regulated as a food supplement in Ireland?

Yes. ageLOC R² Night is classified and sold as a food supplement under EU and Irish regulatory frameworks. Food supplements sold in Ireland are subject to the requirements of the Food Safety Authority of Ireland (FSAI) under SI 506 of 2007 (European Communities (Food Supplements) Regulations), which implements EU Directive 2002/46/EC. As a food supplement, it is not classified as a medicinal product and does not require HPRA authorisation. The standard advisory applies: food supplements should not replace a varied, balanced diet and healthy lifestyle.

What is curcumin's role specifically — and is bioavailability a concern?

Curcumin is known for low intrinsic oral bioavailability in standard forms. Formulators address this through various approaches including phospholipid complexes, nanoparticle encapsulation, or co-delivery with piperine. The curcumin in R² Night is incorporated as part of the overall overnight formulation; if bioavailability is a particular concern for your individual health goals, discussing this with a pharmacist or GP is the appropriate step. Nu Skin's formulation rationale for the specific curcumin form used is best reviewed in their published product documentation.

Works With: The ageLOC R² Ecosystem

• ageLOC R² Day (€66.00) — the daytime counterpart, focused on cellular vitality and energy production support. R² Night + R² Day = the full 24-hour system.
• ageLOC R² Combined Pack (€115.00) — Day + Night together; more economical than purchasing separately.
• Nu Skin LifePak+ (€84.00) — a comprehensive micronutrient supplement providing foundational vitamin, mineral, and antioxidant support that complements R²'s targeted cellular focus.
• Marine Omega (€49.00) — omega-3 fatty acids (EPA/DHA) supporting anti-inflammatory pathways; a logical nutritional companion to R² Night's curcumin component.
• Inner Foundation Package (€207.00) — a curated internal health bundle that includes complementary formulations for a more comprehensive inside-out approach.

Sources & References

• Egner PA, et al. (2014). Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China. Cancer Prevention Research. PMID: 24913818
• Food Safety Authority of Ireland (FSAI) — Food Supplements Regulation: https://www.fsai.ie/legislation/food-legislation/food-supplements
• Nu Skin official product information: nuskin.com
• European Parliament Directive 2002/46/EC on food supplements: EUR-Lex 32002L0046

Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle. Do not exceed the recommended daily intake. Keep out of reach of young children. If you are pregnant, breastfeeding, or have a medical condition, consult your GP or pharmacist before use.

*Independent Nu Skin Brand Affiliate — not produced or endorsed by Nu Skin Enterprises Inc.*