ageLOC® R² (R2) Day (Ireland/EU)

The Mid-Afternoon Slump Has a Cellular Address

Picture the scene: it's 3pm in a Dublin open-plan office. The central heating has been running since October, the sky outside is a familiar shade of grey, and the energy that carried you through the morning has quietly vanished. You reach for another coffee — but what if the problem isn't alertness, it's mitochondrial output? ageLOC® R² Day is formulated specifically for adults who want to support cellular energy production from the inside out, without stimulants, without caffeine, and without a complicated routine. Take two capsules with breakfast, and let the ingredient science do the rest.

At €66.00, R² Day is available as a standalone monthly option — ideal for customers restocking the daytime formula separately, or those exploring the R² system before committing to the full Day + Night combination (€115.00).

Best suited for: Adults over 25 experiencing consistent afternoon energy dips; desk workers in heated indoor environments; anyone seeking cellular-level energy support without stimulants.

Less suited for: Under-25s (mitochondrial energy production is typically still at peak); those already using the full ageLOC R² system (€115.00).

Pairs well with: ageLOC R² Night (€59.00) for 24-hour cellular renewal; Nu Skin LifePak+ (€84.00) for comprehensive micronutrient support; Marine Omega (€49.00) for mitochondrial membrane integrity.

What Makes ageLOC R² Day Different

R² Day is not an energy drink reformulated into a capsule. It targets the biochemical machinery that generates cellular energy — the mitochondria — using three ingredient forms chosen for their evidence of action at that level.

Cordyceps sinensis Cs-4

The defining ingredient. Cs-4 is a standardised, fermentation-derived form of Cordyceps sinensis — not a generic mushroom powder. This matters because bioactive adenosine content varies enormously between crude mushroom extracts and the Cs-4 standardised form. A peer-reviewed clinical study published in the Journal of Alternative and Complementary Medicine (Chen et al., 2010; PMID: 20804368) demonstrated improved aerobic capacity after three weeks of Cordyceps Cs-4 supplementation. The mechanism is mitochondrial: Cs-4 supports ATP synthesis and oxygen utilisation at the cellular level — neither stimulating the central nervous system nor raising heart rate.

Pomegranate Extract

Pomegranate polyphenols are metabolised by gut microbiota into urolithin A, a compound studied for its role in mitophagy — the process by which cells clear damaged mitochondria and support renewal of healthy ones. Research published in Nature Medicine (Ryu et al., 2016; PMID: 28218021) identified urolithin A as a mitophagy inducer with effects on muscle function in ageing models. Including pomegranate extract in a daytime energy formula is a considered formulation decision, not a cosmetic addition.

Chokeberry (Aronia) Extract

Aronia berries have among the highest anthocyanin concentrations of any commercially available fruit. Anthocyanins function as mitochondrial membrane antioxidants — protecting the lipid bilayers of mitochondria from oxidative degradation. In practical terms, this supports the structural integrity of the very organelles the other ingredients are working to energise. Ireland's long indoor heating season and low dietary variety in darker months make this kind of antioxidant support contextually relevant.

How It Compares

Table compares formulation composition and ingredient specificity only. No efficacy ranking implied.

How to Use

Take 2 capsules with breakfast. Do not take in the evening — the formula is designed for daytime metabolic activity. Most users notice changes in sustained afternoon energy within 7–14 days of consistent use.

Frequently Asked Questions

Can I order ageLOC R² Day to an Irish address, and how long does delivery take?

Yes. ageLOC R² Day (€66.00) ships from the EU Nu Skin warehouse directly to Ireland — typically 3–5 business days. Because the shipment originates within the EU single market, there are no customs duties or import charges at the Irish border. No membership or subscription is required to purchase.

Is ageLOC R² Day regulated as a food supplement in Ireland?

Yes. As a food supplement sold in Ireland, R² Day falls under the remit of the Food Safety Authority of Ireland (FSAI) and must comply with EU food supplement regulations. It is not a medicinal product and does not require HPRA authorisation. The EU health claims framework (Regulation EC No 1924/2006) governs what functional claims can be made. Always follow the recommended daily intake on the label.

What does "mitochondrial energy" actually mean for daily life?

Mitochondria are the organelles inside cells that convert nutrients into ATP — the molecule your body uses as direct fuel for cellular processes. As mitochondrial efficiency declines with age and lifestyle stress, this can manifest as persistent tiredness that sleep and caffeine don't fully address. R² Day supports the upstream machinery of ATP production via Cordyceps Cs-4, rather than temporarily masking fatigue with stimulants.

Is this a stimulant or does it contain caffeine?

No caffeine and no stimulant compounds. R² Day works at the mitochondrial level — supporting ATP synthesis and oxygen utilisation through Cordyceps Cs-4. It does not act on the central nervous system and will not cause the energy spike-and-crash pattern associated with caffeine or guarana-based supplements.

Do I need to take R² Night as well, or does Day work on its own?

R² Day works independently as a daytime cellular energy supplement. The ageLOC R² Night (€59.00) formula addresses cellular renewal during sleep — a complementary but distinct function. The complete ageLOC R² system (€115.00) provides both daytime energy support and overnight renewal, which many users find offers more comprehensive results and better value than purchasing each component separately.

Why is R² Day not recommended for under-25s?

Mitochondrial output and cellular energy production are generally at their peak in younger adults. The ageLOC R² system is formulated for adults whose natural cellular energy generation has begun to decline with age. For those under 25, the formula is not considered necessary and has not been studied in that age group for this purpose.

Can I take R² Day alongside other Nu Skin supplements like LifePak+?

Yes — R² Day is commonly used alongside LifePak+ (€84.00) and Marine Omega (€49.00). LifePak+ provides comprehensive micronutrient coverage while R² Day targets the specific mitochondrial energy pathway. If you are taking prescription medication or have an existing health condition, consult your GP or pharmacist before adding any new supplement to your routine.

Works Well With

• ageLOC R² Night (€59.00) — overnight cellular renewal to complete the 24-hour R² system
• ageLOC R² Full System (€115.00) — Day + Night combined for best value
• Nu Skin LifePak+ (€84.00) — comprehensive micronutrient foundation
• Marine Omega (€49.00) — omega-3s supporting mitochondrial membrane health
• Pharmanex Tegreen 120 Capsules (€79.90) — green tea polyphenol antioxidant support

Sources & References

• Chen S, et al. "A randomized, double-blind investigation of the effects of Cs-4 (Cordyceps sinensis) on aerobic capacity and endurance in healthy elderly subjects." Journal of Alternative and Complementary Medicine, 2010. PMID: 20804368
• Ryu D, et al. "Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents." Nature Medicine, 2016. PMID: 28218021
• Nu Skin ageLOC R² product documentation: nuskin.com

Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle. Do not exceed the recommended daily intake. Keep out of reach of young children.

Product information reviewed by the NuBest Skin Editorial Team. Last updated June 2025.

*Independent Nu Skin Brand Affiliate — not produced or endorsed by Nu Skin Enterprises Inc.*