ageLOC R² (R2) (Ireland/EU)

ageLOC R² is a day-and-night supplement system that targets cellular energy production during waking hours and supports your body's natural purification processes overnight. At €115.00 for a complete 30-day supply of both formulas, it sits above the Revive Active or Cleanmarine options you'd find at Boots or Meaghers — but it's one of the few supplements that actually separates active ingredients into circadian-aligned doses rather than packing everything into a single morning sachet. If you've been stacking supplements without shifting that afternoon energy dip, R² takes a fundamentally different approach.

What Makes ageLOC R² Different

The core idea behind R² is straightforward: your body has different needs during the day versus at night. During the day, your mitochondria need to produce ATP efficiently — the fuel every cell runs on. At night, your cells need to clear metabolic waste and repair. Most supplements ignore this distinction entirely. Revive Active, Solgar, and the pharmacy brands deliver everything in one dose and let your body sort it out. R² splits its formula into Day (energy production) and Night (cellular purification), each taken at the appropriate time.

Nu Skin's gene expression research identified specific pathways involved in age-related cellular decline. R² Day targets mitochondrial efficiency using Cordyceps Cs-4, a cultured strain with documented effects on cellular ATP production. A 2019 study in Frontiers in Pharmacology confirmed that Cordyceps Cs-4 supports cellular energy metabolism through multiple pathways — not through stimulant mechanisms like caffeine, but through actual mitochondrial support. R² Night uses milk thistle (silymarin) and broccoli seed extract (a sulforaphane precursor) to support Phase II detoxification enzymes.

Honest caveat: R² isn't a stimulant, and it doesn't work like a cup of tea. You won't feel a noticeable effect 30 minutes after taking it. The effects build over 2-4 weeks of consistent use, and they're subtle — more a "that afternoon slump doesn't hit as hard" than "I'm buzzing." If you're after immediate energy, this isn't the right product.

Key Ingredients

R² Day:

Cordyceps sinensis Cs-4 — a standardised cultured cordyceps strain. A randomised controlled trial in the Journal of Alternative and Complementary Medicine (2010, PMID: 20804368) showed improved aerobic capacity and endurance in healthy adults after 3 weeks of supplementation.

Pomegranate extract — rich in punicalagins and ellagic acid supporting mitochondrial biogenesis. A 2016 study in Nature Medicine (PMID: 28218021) identified urolithin A, a pomegranate metabolite, as a mitochondrial renewal activator.

Chokeberry (Aronia) extract — one of the highest-ORAC-value berries, with anthocyanin antioxidants protecting mitochondrial membranes from oxidative stress.

R² Night:

Milk thistle extract (silymarin) — the most-studied liver-support compound in supplement science. A 2020 meta-analysis in Phytotherapy Research confirmed hepatoprotective properties across 16 clinical trials.

Broccoli seed extract — a concentrated source of glucoraphanin, converted to sulforaphane in the body. Research in Cancer Prevention Research (2014, PMID: 24913818) showed sulforaphane enhanced detoxification of airborne pollutants by 61%.

How to Use

Take 2 R² Day capsules with breakfast. Take 2 R² Night capsules 30 minutes before bed. That's it — roughly 10 seconds morning and evening. Don't take the Day capsules in the evening (Cordyceps may keep you alert) and don't skip the Night capsules. Most users notice a difference in afternoon energy within 7-14 days. The full cellular renewal effects build over a course of 30-90 days.

The Irish climate — mild but damp, overcast for long stretches, indoor heating from October to May — can leave you feeling drained even without obvious cause. R² Day addresses the cellular energy side of that equation. It won't fix the weather, but it supports the underlying machinery that determines how much energy you actually have to work with.

How It Compares

Comparison based on publicly available product information as of 2026. Features and formulations may change.

Who Is This For

Ideal for: Adults over 35 who notice their energy flagging, recovery taking longer, or that general "I don't bounce back like I used to" feeling. Particularly relevant if you've already tried individual supplements (CoQ10, B vitamins, magnesium) from the chemist without noticeable results — R² combines multiple cellular pathways in one system.

Also suited for: People already taking Revive Active who want to add targeted cellular energy and detoxification support. The two don't overlap significantly — Revive Active covers broad-spectrum nutrition, R² targets specific cellular mechanisms.

Not recommended for: Anyone under 25 whose cellular energy production is still at peak efficiency. Also not the right starting point if you haven't addressed sleep, hydration, and basic nutrition first.

Frequently Asked Questions

Can I buy ageLOC R² in Ireland without signing up?
Yes. NuBest Skin sells R² with no Nu Skin membership, no registration, and no subscription. Add to cart and check out — it ships from the official Nu Skin warehouse in Europe.

What's the difference between R² and Revive Active sachets?
Different products for different purposes. Revive Active is a broad-spectrum vitamin, mineral, and CoQ10 sachet — excellent as a daily nutritional foundation. R² specifically targets cellular energy production (Day) and cellular detoxification (Night) through ingredients like Cordyceps and milk thistle that Revive Active doesn't contain. They're complementary rather than interchangeable — you could take both if budget allows.

I already take Cleanmarine. Can I add R²?
Yes. Cleanmarine delivers omega-3 from krill oil — a different mechanism entirely. R² addresses cellular energy and detoxification pathways. Minimal overlap; they complement each other well.

How long should I take R² before judging results?
Allow at least 8 weeks. Afternoon energy typically improves within 7-14 days. Full cellular renewal effects build over 30-90 days of daily use. It's a course, not a quick fix.

Can I combine R² with LifePak+ and Tēgreen?
Yes — they're designed to work together. LifePak+ covers foundational nutrition, R² adds cellular energy and detoxification, Tēgreen provides concentrated antioxidant protection. Minimal overlap between the three.

Works With

LifePak+: R² isn't a multivitamin. Pairing R² with LifePak+ ensures basic nutritional needs are covered while R² handles the cellular energy optimisation. Think of LifePak+ as the foundation, R² as the targeted upgrade.

Beauty Focus Collagen+: Cellular energy production directly affects skin health — your skin cells need ATP to produce collagen and repair UV damage. Supporting energy production (R²) while supplementing collagen peptides (Collagen+) addresses skin ageing from two angles.

MarineOmega: Omega-3 fatty acids support cell membrane fluidity and anti-inflammatory processes. Healthy cell membranes let mitochondria function more efficiently — reinforcing R² Day's energy support.

Important Information

Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle. Do not exceed the recommended daily intake. Keep out of reach of young children. Store in a cool, dry place.

If you are pregnant, breastfeeding, taking medication, or under medical supervision, consult your GP before use.

NuBest Skin is an Independent Nu Skin Brand Affiliate. This website is independently operated and is not produced, endorsed, or approved by Nu Skin Enterprises, Inc.

Sources & References

1. Chen S, et al. "Effect of Cs-4 on exercise performance." Journal of Alternative and Complementary Medicine, 2010. PMID: 20804368.
2. Ryu D, et al. "Urolithin A induces mitophagy and prolongs lifespan." Nature Medicine, 2016. PMID: 28218021.
3. Saller R, et al. "An updated systematic review of milk thistle." Phytotherapy Research, 2020. Meta-analysis of 16 clinical trials.
4. Egner PA, et al. "Detoxication of airborne pollutants by broccoli sprout." Cancer Prevention Research, 2014. PMID: 24913818.
5. Nu Skin Enterprises, Inc. — ageLOC R² product documentation and gene expression research.

Product information reviewed by the NuBest Skin Editorial Team. Last updated April 2026.