Estera® Phase II Women's Transitions Formula (USA)

For Women Navigating the Change — on Their Own Terms

Every day in the United States, approximately 6,000 women reach menopause. That means millions more are in the thick of perimenopause — riding the hormonal rollercoaster of hot flashes that interrupt a Chicago board meeting, night sweats that wreck sleep in a Houston summer, and mood shifts that feel foreign to who you've always been. Estera® Phase II Women's Transitions Formula is a daily botanical supplement designed specifically for women in this active transition window: perimenopause and early menopause. At $64.00 for a 30-day supply, it delivers two of the most-studied natural compounds in women's health — soy isoflavones and black cohosh — for women who want to manage symptoms without hormone replacement therapy (HRT).

Who It's For

• Best suited for: Women in perimenopause or early menopause experiencing hot flashes, night sweats, sleep disruption, or mood fluctuations who prefer a botanical, non-HRT approach to symptom management.
• Also suited for: Women who have previously tried HRT but experienced side effects and are looking for a botanical alternative to discuss with their healthcare provider.
• Less suited for: Women with estrogen-sensitive conditions (certain breast cancers, endometriosis) — phytoestrogens are not appropriate without explicit clearance from your oncologist or gynecologist. Also not the right choice for post-menopausal women who have completed the transition; see Estera® Phase III Women's Maintenance Formula for that stage.
• Pairs well with: LifePak® Anti-Aging Formula for comprehensive micronutrient support alongside hormonal transition; Marine Omega for cardiovascular and mood support during menopause.

What Makes Estera® Phase II Different

The "Phase II" designation is not marketing language — it signals a specific clinical intent. This formula is built for women in active transition, when estrogen levels are fluctuating unpredictably rather than having settled into post-menopausal stability. The formula centers on two cornerstone ingredients with substantial peer-reviewed backing:

Soy Isoflavones (Genistein & Daidzein)

Soy isoflavones are phytoestrogens — plant-derived compounds that bind weakly to estrogen receptors (both ERα and ERβ), providing mild estrogenic activity that helps buffer the dramatic hormonal swings of perimenopause. A meta-analysis published in Menopause (Taku et al., 2012; PMID: 22713856) found that soy isoflavone supplementation reduced hot flash frequency by approximately 21% compared to placebo across multiple randomized controlled trials. The active isoflavones — genistein and daidzein — are the most extensively characterized compounds in this class.

Black Cohosh (Cimicifuga racemosa)

Black cohosh has been investigated in over 30 clinical trials for menopause symptom relief. While its exact mechanism is still being characterized — it may act on serotonin receptors rather than directly on estrogen receptors — it has a long history of use in North American and European women's health traditions. It is among the most frequently recommended botanical options by integrative medicine practitioners for hot flash and mood support during the menopausal transition.

Together, these two ingredients target the core symptom cluster: hot flash frequency and severity, night sweats, and mood fluctuations associated with declining and fluctuating estrogen. This is not a sedative or a quick-relief product — it is daily botanical support that moderates symptoms over a consistent use window of 4–8 weeks.

How It Compares

Table note: Formulation comparisons are based on publicly listed ingredient panels and are intended to help you identify what each formula includes. Estera® Phase II is the only option here that combines specified soy isoflavone fractions (genistein and daidzein) with black cohosh in a formula explicitly positioned for the active perimenopause-to-menopause transition window.

How to Use

Take daily with food. Phytoestrogens and black cohosh require consistent daily use for 4–8 weeks before meaningful symptom reduction is likely to be noticeable. This is not a product for acute relief of a single hot flash — it is a daily foundational supplement designed to moderate the frequency and severity of menopausal symptoms over time. Consistency matters: missing days interrupts the steady-state phytoestrogen activity that makes the formula effective.

Frequently Asked Questions

Does Estera® Phase II ship to the continental US, and do I need a membership to buy it?

Yes to both questions in the best way possible: no membership required, and it ships from the official Nu Skin US warehouse to all 50 states. Continental US orders typically arrive in 3–5 business days. Alaska and Hawaii orders may take additional time.

What is the difference between Phase II and Phase III?

Phase II is formulated for women in active transition — perimenopause and early menopause — when estrogen levels are fluctuating and symptoms like hot flashes and night sweats are most acute. Estera® Phase III Women's Maintenance Formula is designed for women who have completed the transition into post-menopause and want ongoing hormonal balance support at a maintenance level.

How long does it take to notice results?

Clinical data on soy isoflavones and black cohosh consistently shows a 4–8 week window before significant symptom reduction is measurable. This is consistent with how phytoestrogens work — they require time to reach stable receptor activity. If you are evaluating results in week one, give it more time.

Is this a replacement for hormone replacement therapy (HRT)?

No — and this product makes no such claim. Estera® Phase II is a botanical supplement that provides naturally occurring plant compounds studied for menopause symptom support. It is not a pharmaceutical, and it does not replicate HRT pharmacologically. Women with moderate-to-severe menopause symptoms or specific medical needs should have this conversation with their gynecologist or healthcare provider before choosing between HRT, botanical support, or a combination approach.

Is it safe if I have a history of estrogen-sensitive conditions?

This is a critical question that must be answered by your oncologist or gynecologist, not a product description. Phytoestrogens (including soy isoflavones) bind to estrogen receptors, and their appropriateness for women with estrogen-receptor-positive breast cancer, endometriosis, or uterine fibroids is a clinical decision. Do not use this product without professional clearance if you have or have had any estrogen-sensitive condition.

Can I take this alongside other supplements or medications?

Consult your healthcare provider before combining Estera® Phase II with prescription medications, particularly those metabolized by the liver (black cohosh has been studied in the context of hepatic safety) or any hormone-modulating medications. This is standard guidance for any supplement and especially relevant during perimenopause when many women are managing multiple health concerns simultaneously.

Does it need to be refrigerated?

Store in a cool, dry place away from direct sunlight and heat. Refrigeration is not required. Keep out of reach of children.

Is the soy in this product a concern for those with soy allergies?

Soy isoflavones are derived from soy and may be a concern for individuals with soy allergies. If you have a known soy allergy or sensitivity, consult your healthcare provider before use.

Works With: The Estera® & Wellness Ecosystem

• Estera® Phase III Women's Maintenance Formula — the next-stage formula for post-menopausal support once active transition is complete.
• LifePak® Anti-Aging Formula — comprehensive micronutrient support including antioxidants, vitamins, and minerals relevant to women's health during midlife.
• Marine Omega — omega-3 fatty acids for cardiovascular and mood support, both of which are relevant during hormonal transition.
• MYND360™ Night Time — for women whose menopause symptoms include significant sleep disruption, as a complementary evening supplement.
• MYND360™ Feel Calm — mood and stress support that may complement the emotional changes associated with perimenopause.

Sources & References

1. Taku K, et al. "Soy isoflavones for menopausal hot flashes: a systematic review and meta-analysis." Menopause, 2012. PMID: 22713856.
2. Leach MJ, Moore V. "Black cohosh (Cimicifuga spp.) for menopausal symptoms." Cochrane Database of Systematic Reviews, 2012. DOI: 10.1002/14651858.CD007244.pub2.
3. Nu Skin Enterprises, Inc. — Estera® Phase II official US product documentation.

Reviewed by the NuBest Skin Editorial Team. Last updated: May 2025.

*Independent Nu Skin Brand Affiliate — not produced or endorsed by Nu Skin Enterprises Inc.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.