ageLOC® TRME® RealMe (Canada)

ageLOC TRMe RealMe is the appetite and craving management component of Nu Skin's TRMe weight management system, using a clinically studied ingredient blend to help control hunger signals and reduce the impulse eating that derails most weight management efforts. The formula centres on Meratrim (a proprietary blend of Sphaeranthus indicus flower and Garcinia mangostana rind extracts) — an ingredient with two published randomized, double-blind clinical trials showing measurable reductions in body weight, waist circumference, and hip circumference over 8–16 weeks. For Canadians navigating the winter weight cycle — heavier comfort foods, reduced outdoor activity, holiday eating — RealMe targets the appetite signals that make those months particularly challenging.

What Makes ageLOC TRMe RealMe Different

Most appetite suppressants work through stimulant mechanisms — caffeine, synephrine, or other compounds that temporarily blunt hunger by activating the sympathetic nervous system. The problem: they also cause jitters, energy crashes, and tolerance buildup. RealMe takes a non-stimulant approach, using Meratrim to influence adipogenesis (fat cell formation) and leptin signalling rather than artificially suppressing appetite through stimulation.

In the first clinical trial of Meratrim, published in the Journal of Medicinal Food (2013), participants lost an average of 5.2 kg over 16 weeks compared to placebo, with measurable reductions in waist and hip circumference. The second trial, published in Obesity (2014), confirmed these results with a larger participant group. Both studies used the same dose found in RealMe.

RealMe also includes chromium picolinate, which supports healthy blood sugar regulation. Blood sugar spikes and crashes are one of the primary drivers of cravings — particularly the mid-afternoon sugar craving that hits many office workers around 3 PM. By supporting more stable blood sugar levels, chromium reduces the physiological trigger for those cravings.

Key Ingredients

Meratrim (400 mg twice daily): A proprietary blend of Sphaeranthus indicus and Garcinia mangostana extracts. Clinical trials demonstrated effects on three pathways: reducing new fat cell formation (adipogenesis), increasing fat cell breakdown (lipolysis), and reducing fat cell size. Published in the Journal of Medicinal Food (2013) and Obesity (2014).

Chromium Picolinate (200 mcg): Supports insulin sensitivity and glucose metabolism. A meta-analysis in Diabetes Technology & Therapeutics found that chromium supplementation improved fasting blood glucose and HbA1c markers, suggesting meaningful effects on blood sugar regulation.

ageLOC Proprietary Blend: Nu Skin's gene expression targeting ingredients, selected to influence Youth Gene Clusters related to fat metabolism and energy balance. This connects RealMe to the broader ageLOC anti-ageing science platform.

How to Use

Take 2 capsules twice daily — morning and evening, 30 minutes before meals. The pre-meal timing is important: Meratrim needs to be in your system before food arrives to influence appetite signalling effectively.

For best results, use RealMe as part of the full TRMe system (with MyTriumph and SmartWin). However, it also works as a standalone product for those who primarily need appetite and craving management support.

Canadian-specific tip: the hardest months for appetite control are November through February — holiday eating, comfort food season, and reduced activity all converge. Starting RealMe in October, before the holiday gauntlet begins, gives the ingredient blend time to establish in your system.

Stay hydrated — drinking 500 ml of water with your RealMe capsules before meals amplifies the satiety effect. Most Canadians underhydrate in winter because the thirst signal weakens in cold, dry air.

How It Compares

Feature	ageLOC TRMe RealMe	Hydroxycut Pro Clinical	PGX Daily Singles
Active Ingredient	Meratrim (2 clinical trials)	C. canephora robusta (caffeine-based)	PGX fibre (glucomannan blend)
Stimulant-Free	Yes	No (contains caffeine)	Yes
Mechanism	Adipogenesis + appetite signalling	Thermogenic + appetite suppression	Fibre-based satiety
Gene Expression Targeting	Yes (ageLOC)	No	No
Clinical Trials on Formula	2 RCTs (published)	Multiple (on caffeine components)	Multiple (on PGX fibre)
Price	CA$114.99/month	~CA$30/month	~CA$45/month

Hydroxycut is the mass-market leader but relies heavily on caffeine for its effects — if you're caffeine-sensitive or already consuming coffee daily, the stimulant load can be problematic. PGX Daily (a Canadian product from InovoBiologic) uses fibre-based satiety, which works but can cause significant bloating during the adjustment period. RealMe's Meratrim approach offers clinical backing without stimulants or GI discomfort, at a premium price.

Who Is This For

If you struggle with portion control and cravings — particularly the mid-afternoon or post-dinner impulse to snack — RealMe targets the appetite signalling that drives those behaviours. It's not a willpower supplement; it works on the physiological hunger signals themselves.

If you've tried stimulant-based weight management supplements and found them too jittery, sleep-disrupting, or unsustainable, RealMe's non-stimulant approach avoids those issues entirely.

If you're a Canadian professional whose weight management is challenged by a sedentary desk job, business lunches, and the winter comfort-food cycle, RealMe addresses the appetite side while you manage the activity side through whatever exercise routine your climate and schedule allow.

Not suitable for anyone under 18, pregnant or nursing women, or those with eating disorders. If you're taking diabetes medication, consult your healthcare practitioner before use — the chromium component affects blood sugar regulation.

Frequently Asked Questions

Q: How do I buy ageLOC TRMe RealMe in Canada?

Order from nubestskin.com — no membership needed. Ships from the official Nu Skin Canada warehouse. Standard shipping: CA$2.99, free over CA$79. Delivery: 3–5 business days across Canada.

Q: Do I need to buy the full TRMe system or can I use RealMe alone?

RealMe works as a standalone product for appetite management. However, the full TRMe system (RealMe + MyTriumph + SmartWin) targets weight management from three complementary angles: appetite (RealMe), metabolism (MyTriumph), and fat management (SmartWin). Together, they're more effective than any single component.

Q: Is Meratrim safe?

Yes — Meratrim has been evaluated in two published randomized controlled trials with no significant adverse effects reported. It's non-stimulant, non-habit-forming, and does not affect heart rate or blood pressure. The product is registered with Health Canada as a Natural Health Product.

Q: How long before I notice reduced cravings?

Most people report noticeable appetite changes within 1–2 weeks. The clinical trials measured significant results at 8 weeks, with continued improvements through 16 weeks. Consistent daily use is essential — occasional use won't establish the signalling effects.

Q: Can I take RealMe with other supplements?

Yes. RealMe stacks safely with LifePak, Marine Omega, and other Pharmanex supplements. If you're taking the full TRMe system, the three products are designed to work together without interaction concerns.

Works With

ageLOC TRMe MyTriumph: While RealMe manages appetite, MyTriumph supports metabolic rate. Together, they address both sides of the energy balance equation — calories in (appetite) and calories out (metabolism).

ageLOC TRMe SmartWin: Targets fat management through a different mechanism, completing the three-pillar TRMe system. RealMe (appetite) + MyTriumph (metabolism) + SmartWin (fat management) = comprehensive weight management.

ageLOC Meta: While RealMe focuses on appetite and fat cell signalling, Meta supports metabolic gene expression and gut microbiome health. They complement each other — Meta as ongoing metabolic support, RealMe as targeted appetite intervention.

Important Information

Important Information: This product is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare practitioner before use, especially if you are pregnant, nursing, taking medication, or have a medical condition. This product has been assessed by Health Canada as a Natural Health Product. Individual results may vary. Store in a cool, dry place away from direct sunlight.

NuBest Skin is an Independent Nu Skin Brand Affiliate. This content is not produced or endorsed by Nu Skin Enterprises Inc.

Sources & References

Stern, J. S., et al. (2013). Efficacy and tolerability of an herbal formulation for body weight management. Journal of Medicinal Food, 16(6), 529–537.

Lau, F. C., et al. (2014). Efficacy and safety of an herbal formulation for weight management. Obesity, 22(S1), S165.

Balk, E. M., et al. (2007). Effect of chromium supplementation on glucose metabolism and lipids. Diabetes Care, 30(8), 2154–2163.

Reviewed by the NuBest Skin Editorial Team. Last updated: April 2026.