ageLOC® R2 Night + Day (Canada)

ageLOC R² is Nu Skin's dual-supplement system targeting cellular energy and cellular purification — two processes that decline measurably with age. The Day formula (Vitality) supports mitochondrial energy production, while the Night formula supports your body's natural cellular purification processes during sleep. In Nu Skin's clinical studies, participants using R² reported a 25% improvement in physical energy scores over 8 weeks. It's a two-bottle system designed to work with your body's circadian rhythm, not against it.

What Makes ageLOC R² Different

Most anti-ageing supplements target symptoms — low energy, sluggish metabolism, poor sleep. R² targets the underlying cellular mechanisms: mitochondrial ATP production (Day) and autophagic cellular cleanup (Night). These aren't vague "anti-ageing" claims — they're specific biological processes that Nu Skin's gene expression research identified as key drivers of age-related decline.

The ageLOC science platform maps Youth Gene Clusters — groups of genes whose expression changes with age. R²'s ingredient blend was selected specifically to influence gene expression patterns associated with cellular energy and purification, resetting them toward youthful activity levels. Nu Skin's research, conducted in partnership with institutions like LifeGen Technologies, identified these targets through genome-wide gene expression profiling.

The dual-phase approach matters because your body's energy production and cellular cleanup operate on different schedules. Mitochondria are most active during waking hours; autophagy (cellular self-cleaning) peaks during sleep. Delivering the right ingredients at the right time aligns the supplement with your body's natural cycles rather than dumping everything in at once.

Key Ingredients

Cordyceps sinensis (Cs-4 extract) — Day formula: A medicinal mushroom used in traditional Chinese medicine for centuries. Modern research confirms its role in supporting ATP production and oxygen utilization. A randomized controlled trial published in the Chinese Journal of Integrative Medicine showed improved exercise capacity and oxygen uptake in adults taking Cs-4 extract over 12 weeks.

Pomegranate Extract — Night formula: Rich in punicalagins, which support the body's natural cellular purification processes. Research in the journal Metabolism found that pomegranate-derived urolithin A activates mitophagy — the selective cleanup of damaged mitochondria.

Clove Extract — Night formula: Contains eugenol, a potent antioxidant that scores among the highest ORAC (Oxygen Radical Absorbance Capacity) values of any spice-derived compound. Supports antioxidant defence during the overnight recovery window.

Alpha-Lipoic Acid — Day formula: A network antioxidant that supports mitochondrial function and regenerates both vitamins C and E. It's both fat- and water-soluble, giving it access to cellular compartments that most antioxidants can't reach.

How to Use

Take 2 ageLOC R² Day capsules with breakfast each morning. Take 2 ageLOC R² Night capsules with dinner or before bed. Maintaining the morning/evening split is important — the formulas are designed for different phases of your circadian cycle.

For Canadians dealing with seasonal energy shifts — when January's 4:30 PM sunsets and -25°C mornings make everything feel harder — the Day formula's mitochondrial support can make a noticeable difference in sustained energy through those dark months.

Pair with food for best absorption. If you take the Night formula before bed, a small snack with healthy fats helps. Keep bottles at room temperature — avoid the bathroom cabinet (humidity) and certainly don't store them in your car during a Canadian winter.

How It Compares

AOR (an excellent Canadian brand based in Calgary) and Life Extension take a direct mitochondrial support approach with ingredients like PQQ and CoQ10. R²'s differentiation is the circadian split and the gene expression targeting — it's the only product here designed as a day/night system. The price reflects that you're getting two complementary formulas rather than one.

Who Is This For

If you're 35–60 and noticing that your energy doesn't last through a full workday the way it used to — especially during long Canadian winters when seasonal fatigue compounds with natural age-related decline — R²'s dual approach targets the cellular root of that sluggishness.

If you already take a multivitamin (like LifePak) and want to add targeted anti-ageing support, R² works on a different level. LifePak covers nutritional gaps; R² addresses gene expression and cellular processes. They're complementary, not redundant.

If you're a health-conscious professional in Montreal, Calgary, or Ottawa who wants evidence-backed supplementation but doesn't want to manage six different bottles, R² consolidates cellular energy and purification support into one system.

Not recommended if you're under 25 (your cellular processes are likely still operating efficiently), pregnant or nursing, or taking blood-thinning medications without first consulting your healthcare practitioner.

Frequently Asked Questions

Q: Where can I buy ageLOC R² in Canada?

Available at nubestskin.com — no registration or membership required. Ships from Nu Skin's official Canadian warehouse. Standard shipping: CA$2.99, free over CA$79. Delivery: 3–5 business days across Canada.

Q: Can I buy the Day and Night formulas separately?

Yes. ageLOC R² Day (Vitality) is CA$73 and ageLOC R² Night is CA$79.90 individually. The combined Night + Day package at CA$148 saves a few dollars and ensures you have both components of the system.

Q: What's the difference between ageLOC R² and ageLOC Y-Span?

R² focuses specifically on cellular energy (mitochondria) and cellular purification (autophagy). Y-Span targets a broader set of Youth Gene Clusters related to overall ageing processes. Think of R² as targeted cellular maintenance and Y-Span as broader anti-ageing gene expression support. Many people take both.

Q: How long does R² take to work?

Physical energy improvements are typically noticeable within 2–4 weeks. The cellular purification benefits (better sleep quality, improved recovery) usually become apparent at 4–6 weeks. Nu Skin's clinical study measured significant results at the 8-week mark.

Q: Can I stack R² with LifePak or LifePak Nano?

Absolutely — they're designed to complement each other. LifePak handles comprehensive nutritional coverage. R² targets specific cellular processes. There's minimal ingredient overlap, so stacking is both safe and beneficial.

Works With

LifePak or LifePak Nano: Provides the broad nutritional foundation (58 nutrients, antioxidants) that supports the cellular processes R² targets. Think of LifePak as the fuel and R² as the engine tuning.

ageLOC Y-Span: Extends the gene expression approach to a wider set of Youth Gene Clusters. Together, R² and Y-Span provide comprehensive anti-ageing support at the cellular and genetic level.

Tegreen 97: The concentrated EGCG from green tea provides additional antioxidant support that complements R²'s cellular defence mechanisms. Take Tegreen with the Day formula for daytime antioxidant synergy.

Important Information

Important Information: This product is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare practitioner before use, especially if you are pregnant, nursing, taking medication, or have a medical condition. This product has been assessed by Health Canada as a Natural Health Product. Individual results may vary. Store in a cool, dry place away from direct sunlight.

NuBest Skin is an Independent Nu Skin Brand Affiliate. This content is not produced or endorsed by Nu Skin Enterprises Inc.

Sources & References

Chen, S., et al. (2010). Effect of Cs-4 (Cordyceps sinensis) on exercise performance in healthy older subjects. Chinese Journal of Integrative Medicine, 16(6), 585–590.

Ryu, D., et al. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature Medicine, 22, 879–888.

Nu Skin Enterprises. (2024). ageLOC R² Clinical Study Results — Gene Expression and Vitality Outcomes.

Reviewed by the NuBest Skin Editorial Team. Last updated: April 2026.