ageLOC® R2 Night (Canada)

ageLOC R² Night is the evening component of Nu Skin's R² cellular system, targeting cellular purification — the autophagy and detoxification processes your body ramps up during sleep. While R² Day supports daytime energy production, R² Night supports the overnight cleanup that removes damaged cellular components, oxidized proteins, and metabolic waste. The formula combines pomegranate extract (rich in punicalagins), clove extract (high-ORAC antioxidant), and the ageLOC gene expression blend targeting purification-related Youth Gene Clusters. For Canadians, the nighttime purification support complements the body's natural repair cycle during the long winter sleep hours.

What Makes ageLOC R² Night Different

Sleep supplements usually focus on helping you fall asleep — melatonin, valerian, magnesium. R² Night doesn't address sleep onset; it supports what your body does while you're asleep. Cellular purification (autophagy) naturally peaks during sleep, cleaning up damaged mitochondria, misfolded proteins, and oxidative waste that accumulates during the day.

Research published in Nature Medicine (2016) demonstrated that pomegranate-derived urolithin A activates mitophagy — the selective cleanup of damaged mitochondria. This process is critical for maintaining cellular health: keeping damaged mitochondria active is like running a factory with broken equipment.

The clove extract provides exceptionally high antioxidant activity (ORAC values among the highest of any spice-derived compound), supporting the overnight antioxidant defence that protects newly purified cells from immediate re-oxidation.

Key Ingredients

Pomegranate Extract (Punicalagins): Supports cellular purification through urolithin A production, which activates mitophagy — the selective removal of damaged mitochondria. Published research in Nature Medicine confirms the mechanism.

Clove Extract (Eugenol): One of the highest-ORAC natural antioxidants, providing overnight antioxidant protection during the cellular repair window.

ageLOC Proprietary Blend: Targets Youth Gene Clusters associated with cellular purification, supporting youthful autophagy gene expression during sleep.

How to Use

Take 2 capsules with dinner or before bed. The evening timing aligns with your body's natural circadian purification cycle — autophagy peaks during sleep, and R² Night supports this peak activity.

During Canadian winters, longer sleep periods (many Canadians sleep 30–60 minutes more in winter due to longer dark hours) provide an extended purification window. R² Night makes the most of this naturally extended repair time.

Frequently Asked Questions

Q: How do I purchase ageLOC R² Night in Canada?

Order at nubestskin.com — no membership required. Ships from the official Nu Skin Canada warehouse. Standard shipping: CA$2.99, free over CA$79. Delivery: 3–5 business days.

Q: Will this help me sleep?

R² Night doesn't contain sleep-inducing ingredients. It supports what your body does during sleep (cellular purification), not the sleep process itself. If you have sleep issues, address those separately.

Q: Can I take R² Night without R² Day?

Yes — R² Night provides standalone cellular purification support. The combined system (Day + Night) targets both energy and purification for comprehensive cellular health, but each product has independent benefits.

Q: How long before I notice results?

Improved sleep quality (waking more refreshed) is often reported within 2–3 weeks. Full cellular purification benefits develop over 6–8 weeks of consistent nightly use.

Q: Is there any overlap with Y-Span?

Minimal. R² Night specifically targets cellular purification. Y-Span targets broader ageing gene clusters (cardiovascular, immune, metabolic). They complement each other — R² Night cleans up cells; Y-Span influences how cells age.

Important Information

Important Information: This product is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare practitioner before use, especially if you are pregnant, nursing, taking medication, or have a medical condition. This product has been assessed by Health Canada as a Natural Health Product. Individual results may vary. Store in a cool, dry place away from direct sunlight.

NuBest Skin is an Independent Nu Skin Brand Affiliate. This content is not produced or endorsed by Nu Skin Enterprises Inc.

Sources & References

Ryu, D., et al. (2016). Urolithin A induces mitophagy and prolongs lifespan. Nature Medicine, 22, 879–888.

Nu Skin Enterprises. (2024). ageLOC R² Night — Cellular Purification Gene Expression Data.

Reviewed by the NuBest Skin Editorial Team. Last updated: April 2026.