ageLOC® R2 Night (Canada)

From October through March, most Canadians spend nine or more hours in darkness — and whether you're in Winnipeg dealing with minus-30 nights or in Vancouver under a perpetual overcast sky, your body uses that extended sleep window for something remarkable: cellular housekeeping. Autophagy — the biological process that removes damaged mitochondria, oxidised proteins, and metabolic waste — peaks during sleep. ageLOC® R² Night (CA$79.90) is formulated specifically for this overnight biological window, delivering pomegranate extract, clove extract, and Nu Skin's ageLOC proprietary blend to support the cellular purification processes most active while you sleep. Canada's long winter nights aren't just something to endure — with the right support, they're an extended repair opportunity.

Who ageLOC® R² Night Is For

Best Suited For

• Adults over 35 looking to support cellular purification as part of a structured nightly supplement routine
• Those already using ageLOC® R² Day who want to complete the 24-hour cellular health system
• Canadians whose bodies face cumulative daily stress — Prairie cold, urban commutes, indoor forced-air heating — and want to support overnight recovery
• Anyone interested in longevity science and the emerging research on mitophagy and cellular renewal

Less Suited For

• Those looking for sleep onset support — R² Night does not contain melatonin, valerian, or magnesium; it supports what your body does during sleep, not the process of falling asleep
• Individuals under 18, or those who are pregnant or nursing (consult your healthcare practitioner before use)

Pairs Well With

• ageLOC® R² Day (Vitality) — the complementary daytime formula targeting cellular energy production, completing the full R² protocol
• ageLOC® Y-Span® — targets broader ageing gene clusters (cardiovascular, immune, metabolic), working alongside R² Night's cellular purification focus

What Makes ageLOC® R² Night Different

Most sleep supplements are designed to help you fall asleep — not to support the complex cellular biology that unfolds during the hours you're already asleep. R² Night occupies a different category entirely.

Cellular purification (autophagy) naturally ramps up during sleep, clearing damaged mitochondria, misfolded proteins, and oxidative waste that accumulates throughout the day. Research published in Nature Medicine (2016) demonstrated that pomegranate-derived urolithin A activates mitophagy — the selective removal of damaged mitochondria — a process that declines with age and is considered central to how cells age over time.

Clove extract contributes one of the highest ORAC (Oxygen Radical Absorbance Capacity) values of any plant-derived compound, providing antioxidant defence during the overnight repair window — protecting newly purified cells from immediate re-oxidation.

The ageLOC proprietary blend targets Youth Gene Clusters specifically associated with cellular purification, supporting youthful autophagy gene expression patterns during sleep. This gene-expression approach is what distinguishes the ageLOC system from standard antioxidant supplements that simply deliver reactive oxygen species scavengers without addressing the underlying cellular regulation.

For context: Canadian winters naturally extend sleep duration for many people — research suggests adults in northern climates may sleep 30–60 minutes longer during the darkest months due to increased melatonin output in response to reduced daylight. R² Night is formulated to make productive use of that biologically extended repair window.

Key Ingredients

• Pomegranate Extract (Punicalagins): Supports cellular purification through urolithin A production, which activates mitophagy — the selective removal of damaged mitochondria. The mechanism is documented in peer-reviewed research (Nature Medicine, 2016).
• Clove Extract (Eugenol): Among the highest-ORAC natural antioxidants available, providing overnight antioxidant protection during the cellular repair cycle.
• ageLOC Proprietary Blend: Targets Youth Gene Clusters associated with cellular purification, supporting youthful autophagy gene expression patterns during sleep.

How to Use

Take 2 capsules with dinner or before bed. The evening timing aligns with your body's natural circadian purification cycle — autophagy peaks during sleep, and R² Night supports this peak activity.

During Canadian winters, longer sleep periods (many Canadians sleep 30–60 minutes more in winter due to longer dark hours) provide an extended purification window. R² Night makes the most of this naturally extended repair time.

How ageLOC® R² Night Compares

Comparison based on publicly available formulation data. Bioavailability and clinical outcomes vary by individual. This table does not imply equivalence of function between products.

Frequently Asked Questions

How do I order ageLOC® R² Night in Canada, and how long does shipping take?

ageLOC® R² Night is available at nubestskin.com/ca — no membership required. The product ships from Nu Skin's official Canadian warehouse. Standard delivery is typically 3–7 business days across most of Canada; remote and Northern communities may require additional transit time.

Will ageLOC® R² Night help me fall asleep?

No — R² Night does not contain sleep-onset ingredients such as melatonin, valerian root, or magnesium glycinate. Its purpose is to support the cellular purification biology that occurs during sleep, not to initiate or deepen sleep itself. If you have difficulty sleeping, that is a separate concern to address with your healthcare practitioner.

Can I take ageLOC® R² Night on its own, without R² Day?

Yes. R² Night provides standalone cellular purification support and is formulated to deliver independent benefit. The complete R² system — Day plus Night — targets both cellular energy production (daytime) and cellular purification (overnight) for a comprehensive 24-hour protocol, but each product functions independently.

How soon might I notice a difference?

Some users report waking feeling more refreshed within 2–3 weeks of consistent nightly use. Full cellular purification benefits, as with most cellular-level supplements, typically develop over 6–8 weeks of regular use.

Is there any overlap between ageLOC® R² Night and ageLOC® Y-Span®?

Minimal overlap. R² Night specifically targets cellular purification processes (autophagy, mitophagy). ageLOC® Y-Span® addresses broader ageing gene clusters related to cardiovascular, immune, and metabolic function. The two products are designed to complement rather than duplicate each other.

Does ageLOC® R² Night require Health Canada approval to be sold in Canada?

Yes. Natural health products sold in Canada are regulated by Health Canada under the Natural Health Products Regulations. Look for the NPN (Natural Product Number) on the label — this confirms Health Canada has reviewed the product for safety, efficacy, and quality before it reaches Canadian consumers.

How does ageLOC® R² Night differ from standard antioxidant supplements available at Shoppers Drug Mart or Costco?

Products such as Jamieson Antioxidant Complex or Webber Naturals antioxidant formulas are primarily designed to scavenge free radicals — an important but generalised function. R² Night is formulated around a specific biological target: the circadian peak of autophagy and mitophagy during sleep, using pomegranate-derived punicalagins (urolithin A precursor) and the ageLOC gene expression blend. The formulation approach — timing and gene expression targeting — is distinct from broad antioxidant supplementation.

Works With

• ageLOC® R² Day (Vitality) — CA$73.00 — the daytime counterpart, targeting cellular energy; together with R² Night, forms the complete 24-hour R² cellular health protocol
• ageLOC® R² Night + Day — CA$148.00 — the combined bundle for those starting the full R² system
• ageLOC® Y-Span® — CA$155.00 — broader ageing gene cluster support, complementing R² Night's cellular purification focus
• ageLOC® Meta — CA$136.00 — metabolic support to pair with cellular-level ageing protocols
• LifePak® Nano Anti-aging Multivitamins — CA$189.00 — comprehensive micronutrient foundation to support overall cellular health alongside R² Night

Sources & References

• Ryu, D., et al. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature Medicine, 22, 879–888. https://www.nature.com/articles/nm.4132
• Levine, B., & Kroemer, G. (2008). Autophagy in the pathogenesis of disease. Cell, 132(1), 27–42. https://www.cell.com/cell/fulltext/S0092-8674(07)01685-5
• Health Canada — Natural Health Products Regulations: https://www.canada.ca/en/health-canada/services/drugs-health-products/natural-non-prescription.html

Look for the NPN (Natural Product Number) on the label — this confirms Health Canada has reviewed ageLOC® R² Night for safety, efficacy, and quality before it is sold in Canada.

This product is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare practitioner before use, especially if you are pregnant, nursing, taking medication, or have a medical condition. Individual results may vary. Store in a cool, dry place away from direct sunlight.

*Independent Nu Skin Brand Affiliate — not produced or endorsed by Nu Skin Enterprises Inc.*