ageLOC® Tru Face® Essence Ultra (UK)

ageLOC Tru Face Essence Ultra is Nu Skin's most clinically tested firming serum — and it's built around Ethocyn, a patented compound shown in published research to increase the ratio of functional elastin in skin by up to 200%. In Nu Skin's own 12-week clinical study of 50 participants, 100% reported visibly firmer, more contoured skin by week four. If you're dealing with loss of definition along the jawline or sagging around the cheeks — particularly common in your 40s and beyond — this is the product the Tru Face range was designed around.

What Sets Tru Face Essence Ultra Apart

Most firming serums rely on peptides alone, which work well for fine lines but don't address the deeper structural changes that cause skin to lose its contour. Essence Ultra takes a different approach: Ethocyn targets elastin production specifically, which is the protein responsible for skin's ability to snap back into place. After about age 25, elastin production drops sharply — by your 40s, skin retains only a fraction of its original elasticity. Ethocyn doesn't just slow that decline; in clinical testing, it actively increased functional elastin levels.

The formula also includes Coenzyme Q10 (CoQ10), a naturally occurring antioxidant that supports cellular energy production in skin cells. As CoQ10 levels decline with age, skin becomes more vulnerable to environmental stressors — everything from central heating in winter to the hard water that's common across London, the South East, and the Midlands. The ageLOC blend rounds out the formula by targeting gene expression clusters associated with visible ageing.

Key Ingredients

Ethocyn (ethoxylated polyol compound): Patented active that increases the proportion of functional elastin fibres in the dermis. Published data shows up to 200% improvement in the functional elastin ratio over 12 weeks of consistent use.

Coenzyme Q10: Lipid-soluble antioxidant that supports mitochondrial energy production in skin cells. Levels naturally decline from your late 20s onward.

ageLOC blend: Nu Skin's proprietary complex designed to target sources of ageing at the gene expression level, focusing on clusters related to collagen maintenance and cellular renewal.

How to Get the Most from Tru Face Essence Ultra

Apply one capsule to clean, dry skin each evening, focusing on the jawline, cheeks, and neck — the areas where firmness loss shows first. Each capsule contains a pre-measured dose, so there's no guesswork. Twist the tab, squeeze the serum onto your fingernails, and press gently into skin using upward strokes.

For best results, use after cleansing with the Tru Face Refining Toner and before your evening moisturiser. The single-dose capsules also travel well — no risk of spillage, no need for a separate travel bottle. In the UK's drier winter months, when central heating strips moisture from skin, pairing Essence Ultra with the Uplifting Rich Cream gives the best overnight recovery.

How Does Tru Face Essence Ultra Compare?

Comparison based on publicly available product information as of April 2026. No price comparisons included.

Frequently Asked Questions

How quickly is Tru Face Essence Ultra delivered in the UK?
Orders placed through NuBest Skin are fulfilled from the official Nu Skin UK warehouse. Standard delivery typically arrives within 3–5 working days, and no Nu Skin membership or registration is required to purchase.

Can I use Essence Ultra with retinol products?
Yes. Ethocyn works on elastin pathways rather than cell turnover, so it won't conflict with retinoids. Many people in the Tru Face range combine Essence Ultra (evening) with the Peptide Retinol Complex on alternate nights, or use both in the same routine — Essence Ultra first, retinol second.

How many capsules are in each bottle?
Each bottle contains 60 capsules, which is a 30-day supply when used twice daily or a 60-day supply at the recommended once-daily evening application.

Is this suitable for sensitive skin?
The capsule format means no preservatives are needed in the serum itself — each dose is sealed until use. That said, if you have very reactive skin, do a patch test on your inner forearm 24 hours before first use. The formula is fragrance-free.

What's the difference between the full bottle and the refill?
The refill (ID 587) contains the same 60 capsules in a lightweight pouch rather than the glass bottle. It's designed to slot into your existing bottle, reducing packaging waste by approximately 60%.

Important Information

Individual results may vary. This product is intended for cosmetic use only and is not designed to diagnose, treat, cure, or prevent any disease or skin condition. Discontinue use if irritation occurs and consult a dermatologist or your GP. Patch test recommended before first use.

Clinical results referenced are from studies conducted or commissioned by Nu Skin Enterprises, Inc. and may not reflect typical consumer experience.

NuBest Skin is an Independent Nu Skin Brand Affiliate. This website is independently operated and is not produced, endorsed, or approved by Nu Skin Enterprises, Inc.

Sources & References

1. Nu Skin Enterprises, Inc. — ageLOC Tru Face Essence Ultra product page and clinical study summary. nuskin.com/gb
2. Ethocyn clinical research — published data on elastin ratio improvement (referenced in Nu Skin product documentation, 2024).
3. Coenzyme Q10 in dermatology — Hoppe U. et al., BioFactors, 1999; 9(2-4): 371-378.
4. Nu Skin ageLOC science overview — gene expression cluster targeting methodology. nuskin.com/gb/en/ageloc

Product information reviewed by the NuBest Skin Editorial Team. Last updated April 2026.