ageLOC® R² (R2) Night (UK)

The Supplement Built Around What Your Body Does While You Sleep

You finish a long day at the office — the air conditioning has been running since 9am, you've taken two Underground journeys through some of London's most particulate-laden air, and your body has been quietly accumulating the kind of low-grade environmental burden that city life makes unavoidable. Now, at night, your liver and cellular detoxification machinery shift into their highest gear. ageLOC R² Night (£59.90) is formulated specifically for that biological window — delivering milk thistle extract (80% silymarin), broccoli seed extract (sulforaphane glucosinolate), and resveratrol when your body's own purification enzyme activity peaks during sleep. It is the standalone evening component of Nu Skin's R² system, available separately for those who already hold the Day formula or who want to prioritise the overnight detoxification and antioxidant pathway support specifically.

Best suited for: Urban commuters in London, Manchester, Birmingham, or Leeds exposed to elevated PM2.5 and NO₂ levels daily; adults who consume alcohol regularly and wish to support ongoing liver function; anyone over 35 looking to support cellular detoxification as part of a structured supplement routine; existing R² Day users wanting to complete the 24-hour system.

Less suited for: Those expecting an acute "detox" or hangover remedy — this supports ongoing biochemical processes, not short-term recovery. Anyone with an existing liver condition should consult their GP before use.

Pairs well with: ageLOC R² Day (£62.88) for the complete circadian system; Beauty Focus Collagen+ (£59.90) for an inside-out approach to skin and cellular health; LifePak+ (£79.90) for broader micronutrient support.

What Makes R² Night Different

The British supplement market is saturated with products making loosely defined "detox" claims — from Holland & Barrett's herbal blends to own-label liver support capsules. R² Night occupies a different category because it targets two specific, well-characterised biochemical pathways rather than relying on vague cleansing language.

Pathway 1: Nrf2 Activation. Nrf2 (Nuclear factor erythroid 2–related factor 2) is the body's master switch for antioxidant enzyme production. When activated, it upregulates enzymes including superoxide dismutase, glutathione peroxidase, and catalase — the body's own protective proteins. This is fundamentally different from consuming external antioxidants like vitamin C; rather than adding antioxidants from outside, Nrf2 activation tells your own cells to produce more of their own. Sulforaphane from broccoli seed extract is one of the most potent natural Nrf2 activators identified in the scientific literature.

Pathway 2: Phase II Hepatic Detoxification. This is the liver's metabolic process that conjugates environmental toxins — attaching water-soluble molecules to fat-soluble pollutants so they can be excreted. Milk thistle's silymarin has hepatoprotective effects supported by decades of clinical research and a formal European Medicines Agency monograph, giving it a regulatory standing that most "liver support" supplements simply do not have.

Circadian Timing. The timing of R² Night is not arbitrary. Research published in Cell Metabolism has documented that detoxification enzyme activity follows circadian rhythms, with peak activity occurring during sleep. Delivering these active compounds in the evening aligns with the biological window in which your body's purification machinery is operating at its highest capacity.

Key Ingredients

Milk Thistle Extract (80% Silymarin)

Silymarin is a flavonoid complex extracted from Silybum marianum and is among the most extensively studied hepatoprotective compounds in botanical medicine. The EMA monograph on milk thistle confirms its established use for supportive treatment of liver conditions. In the context of R² Night, standardised to 80% silymarin, it supports the liver's capacity to process the environmental toxins accumulated across a typical urban British day — including elevated NO₂ from road traffic and particulate matter from commuter environments. The London Underground, according to Transport for London's own air quality monitoring, carries particulate levels significantly above street level.

Broccoli Seed Extract (Sulforaphane Glucosinolate)

Sulforaphane is produced when glucoraphanin (present in broccoli seed) is hydrolysed by the enzyme myrosinase. It is one of the most potent natural Nrf2 pathway activators identified in peer-reviewed research. A study by Kensler TW et al. (Cancer Prevention Research, 2012) demonstrated increased excretion of airborne pollutant metabolites in participants taking broccoli sprout extract — directly relevant for anyone regularly exposed to urban pollution across British cities. The broccoli seed extract form (sulforaphane glucosinolate) is the precursor form used for stability in supplement manufacture.

Resveratrol and Additional Polyphenols

Resveratrol has been studied for its effects on cellular longevity pathways, including sirtuin activation (SIRT1). It complements the Nrf2 pathway activation from sulforaphane through a distinct mechanism, providing a secondary layer of antioxidant defence. Together with the additional polyphenols in the formula, it rounds out R² Night's approach to overnight cellular protection.

How R² Night Compares

Feature	ageLOC R² Night	Vitabiotics Perfectil Night	Holland & Barrett Milk Thistle	Solgar Full Spectrum Curcumin
Primary Mechanism	Nrf2 pathway activation + phase II liver detoxification	General micronutrient support; biotin, zinc, iron for beauty	Single-ingredient liver support	Curcumin anti-inflammatory; no hepatic detox pathway targeting
Milk Thistle Standardisation	80% silymarin — pharmaceutical-grade standardisation	Not included	Standardisation level not prominently disclosed	Not included
Sulforaphane / Nrf2 Activator	Broccoli seed extract (SFG)	Not included	Not included	Not included
Circadian Timing Design	Yes — formulated for evening/sleep window	Designed as a night formula but focused on hair/skin nutrients	No circadian targeting	No circadian targeting
Resveratrol / Polyphenol Complex	Included	Not included	Not included	Curcumin only
Part of Dual-Phase System	Yes — pairs with R² Day for 24-hour coverage	Pairs with Perfectil Day (beauty nutrients)	No	No

Formulation comparison based on publicly available product information. Ingredient quality and standardisation levels vary significantly across supplement categories and are not equivalent in mechanism.

How to Use

Take 2 capsules in the evening with your last meal. The circadian timing is important — these ingredients are designed to support overnight purification processes that peak during sleep. Taking them in the morning is not harmful, but it misses the biological window where detoxification enzyme activity is at its highest. Pair with ageLOC R² Day (£62.88) (sold separately or as a set at £109.00) for the complete 24-hour system. Effects are cumulative — most users report improved morning alertness and clearer skin from weeks 4–8 of consistent use.

Frequently Asked Questions

Does ageLOC R² Night ship to UK addresses, and how long does delivery take?

Yes. R² Night ships from the Nu Skin UK warehouse and typically arrives within 2–4 business days across the UK mainland. Standard UK delivery applies; no cross-border EU shipping is involved post-Brexit, so there are no customs delays or additional import charges for UK customers.

Do I need to purchase R² Day at the same time, or can I start with Night alone?

R² Night works as a standalone supplement targeting overnight detoxification and Nrf2 antioxidant pathway support. The Day formula addresses daytime cellular energy and protection through different mechanisms. You can begin with Night alone — particularly relevant if your primary interest is supporting liver detoxification and antioxidant enzyme activity — and add the Day component later. The R² complete set (£109.00) offers both formulas for the full 24-hour system.

Is this regulated as a food supplement in the UK?

Yes. ageLOC R² Night is classified as a food supplement and falls under the oversight of the Food Standards Agency (FSA) in the UK. It is not a medicinal product and does not require MHRA authorisation. The milk thistle component has an EMA monograph supporting its hepatoprotective use, but this supplement makes no medicinal claims. As with all food supplements, it is intended to complement a balanced diet, not replace it.

Is this the same as a "detox" juice cleanse or teatox product?

No — and the distinction is meaningful. R² Night targets two specific, well-characterised biochemical pathways: Nrf2 antioxidant enzyme activation (which upregulates your body's own protective enzymes) and phase II hepatic detoxification (the liver's conjugation and excretion process for environmental toxins). These are real, peer-reviewed biochemical mechanisms. Your body detoxifies itself naturally; R² Night aims to support the efficiency of those natural processes. It does not claim to "flush toxins" in the undefined, marketing-led sense common to many detox products.

Is R² Night relevant for someone who drinks alcohol socially — for example, post-pub recovery?

R² Night is designed to support the liver's ongoing detoxification capacity, which includes processing ethanol metabolites. It is not an acute hangover remedy and will not undo the effects of a heavy Friday night in real time. However, regular use to support liver function and antioxidant enzyme production is relevant for adults who consume alcohol regularly, even at moderate levels. If you have an existing liver condition, consult your GP before starting any liver-support supplement.

Can London Underground commuters specifically benefit from R² Night?

This is a reasonable question given the published data. Transport for London's own air quality monitoring has recorded particulate matter levels significantly above street level on several Underground lines, particularly on older deep-tube sections. PM2.5 exposure of this kind creates oxidative stress that the body processes primarily during sleep. The broccoli seed extract's sulforaphane component has been studied specifically in the context of airborne pollutant excretion (Kensler et al., 2012), and the circadian timing of R² Night aligns with overnight detoxification enzyme peaks — making it a logical fit for high-pollution commuting environments across British cities.

How long before I notice a difference?

R² Night's effects are cumulative and work at the cellular and enzymatic level — this is not a product with an immediate visible or felt result. Most users report improved morning alertness and changes in how their skin looks and feels between weeks 4 and 8 of consistent daily use. Biochemical pathway support of this kind requires sustained supplementation to produce meaningful upregulation of antioxidant enzyme activity.

Works With

• ageLOC R² Day (£62.88) — The daytime partner formula targeting cellular energy and daytime antioxidant protection. Together with R² Night, completes the full circadian detoxification and protection system.
• ageLOC R² Complete Set (£109.00) — Day and Night together at a combined price.
• Beauty Focus Collagen+ (£59.90) — An ingestible collagen supplement for skin structure support, complementing R² Night's cellular health approach from a different angle.
• LifePak+ (£79.90) — Nu Skin's comprehensive micronutrient supplement providing the foundational vitamin and mineral support that underpins the R² system's more targeted pathway work.
• Marine Omega (£45.27) — Omega-3 fatty acids supporting cellular membrane integrity and anti-inflammatory pathways alongside the antioxidant defence focus of R² Night.

Sources & References

• Kensler TW, et al. "Modulation of the Metabolism of Airborne Pollutants by Glucoraphanin-Rich and Sulforaphane-Rich Broccoli Sprout Beverages in Szechuan, China." Cancer Prevention Research, 2012. PubMed reference
• European Medicines Agency. "Community herbal monograph on Silybum marianum (L.) Gaertn., fructus." EMA/HMPC/294817/2011. EMA monograph
• Panda S, et al. "Circadian physiology of metabolism." Science, 2016; 354(6315):1008–1015. PubMed
• Itoh K, et al. "Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles." Genes to Cells, 2003. Referenced for Nrf2 pathway mechanism. PubMed
• Transport for London. Air Quality on the Transport for London Network. TfL Air Quality Data
• Food Standards Agency (FSA). Food supplements — regulatory framework in the UK. FSA.gov.uk

*Independent Nu Skin Brand Affiliate — not produced or endorsed by Nu Skin Enterprises Inc.