ageLOC® R² (R2) Night (UK)

ageLOC R² Night is the evening component of Nu Skin's R² supplement system, formulated to support the body's natural overnight purification and cellular repair processes. It contains milk thistle extract (80% silymarin), broccoli seed extract (sulforaphane glucosinolate), and additional antioxidant compounds that target Nrf2 pathway activation — the body's master switch for antioxidant enzyme production. At £59.90, it's the standalone night formula for those who already have the Day component or want to focus specifically on detoxification support. It's particularly relevant for anyone living in a UK city — if you commute through London, Birmingham, or Manchester, you're accumulating pollutant exposure that your body processes primarily during sleep.

What Makes R² Night Different

Most "detox" supplements are marketing nonsense. R² Night is not. It targets specific, well-characterised biochemical pathways: Nrf2 activation (which upregulates your body's own antioxidant enzymes — superoxide dismutase, glutathione peroxidase, catalase) and phase II liver detoxification (the metabolic process that conjugates and excretes environmental toxins). These are real pathways studied in real journals, not vague "cleansing" claims.

The timing is based on circadian biology. Detoxification enzyme activity follows 24-hour patterns, peaking during sleep — research in Cell Metabolism has documented this rhythm. R² Night delivers its active compounds when the body's purification machinery is most active. Milk thistle's hepatoprotective effects are supported by decades of clinical use and a European Medicines Agency monograph. Broccoli seed extract's sulforaphane is one of the most potent natural Nrf2 activators identified in research (Kensler TW, et al., Cancer Prevention Research, 2012).

Key Ingredients

Milk Thistle Extract (80% Silymarin) — Hepatoprotective compound that supports phase II liver detoxification. Has decades of clinical use and EMA approval for supportive treatment of liver conditions. In R² Night, it supports the liver's capacity to process environmental toxins accumulated during the day — particularly relevant for urban commuters exposed to elevated PM2.5 and NO₂ levels.

Broccoli Seed Extract (Sulforaphane Glucosinolate) — One of the most potent natural Nrf2 pathway activators. A 2012 study demonstrated increased excretion of airborne pollutant metabolites in participants taking broccoli sprout extract. Nrf2 activation upregulates the body's own antioxidant enzymes — a fundamentally different approach from simply consuming external antioxidants like vitamin C.

Resveratrol and Additional Polyphenols — Support antioxidant defence and have been studied for their effects on cellular longevity pathways, including sirtuin activation. Resveratrol complements the Nrf2 pathway activation from sulforaphane through a different mechanism.

How to Use

Take 2 capsules in the evening with your last meal. The circadian timing is important — these ingredients are designed to support overnight purification processes. Taking them in the morning won't harm you, but it misses the biological window where detoxification enzyme activity is highest. Pair with R² Day (sold separately or as a set at £109.00) for the complete 24-hour system. Effects are cumulative — most people notice improved morning alertness and clearer skin from week 4-8.

Who Is This For

Anyone living in a UK city who's exposed to daily pollution — particularly London Underground commuters, where particulate matter levels are significantly higher than street level according to Transport for London's own monitoring. Also suited for adults who consume alcohol regularly (even moderately), eat processed foods, or simply want to support their liver's detoxification capacity as they age. Not a hangover cure — it supports ongoing detoxification processes, not acute alcohol recovery. Consult your GP if you have an existing liver condition.

Frequently Asked Questions

Can I buy R² Night without a membership?
Yes. NuBest Skin sells it directly — no Nu Skin account, no subscription. Ships from the official UK warehouse.

Is this a "detox" supplement?
Not in the vague, juice-cleanse sense. R² Night supports specific, well-characterised biochemical detoxification pathways — Nrf2 antioxidant enzyme activation and phase II hepatic conjugation. These are real biochemical processes, not marketing concepts. Your body detoxifies itself naturally; R² Night aims to support the efficiency of that natural process.

Can I take this without the Day formula?
Yes. R² Night works independently for purification and antioxidant support. The full system (Day + Night) addresses both energy and detoxification across the 24-hour cycle, but Night alone provides meaningful benefits for anyone focused on detoxification and overnight recovery.

Important Information

Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle. Do not exceed the recommended daily intake. Keep out of reach of young children. Store in a cool, dry place.

If you are pregnant, breastfeeding, taking medication, or under medical supervision, consult your GP before use.

NuBest Skin is an Independent Nu Skin Brand Affiliate. This website is independently operated and is not produced, endorsed, or approved by Nu Skin Enterprises, Inc.

Sources & References

• Kensler TW, et al. "Broccoli sprout extract and pollutant excretion." Cancer Prevention Research, 2012.
• European Medicines Agency. Community herbal monograph on Silybum marianum (milk thistle).

Product information reviewed by the NuBest Skin Editorial Team. Last updated April 2026.