ageLOC® R² (R2) Day (UK)

ageLOC R² Day is the daytime component of Nu Skin's R² supplement system, formulated specifically to support mitochondrial energy production during waking hours. It contains Cordyceps sinensis Cs-4, pomegranate extract, and alpha lipoic acid — ingredients selected for their effects on cellular ATP production and antioxidant defence. At £62.88, it's available as a standalone purchase for those who already have the Night component stocked or want to trial the energy formula before committing to the full R² system at £109.00. We noticed a genuine difference in sustained afternoon energy from around week three — the kind of steady alertness that doesn't come with the jittery edge of caffeine.

What Makes R² Day Different

Most energy supplements rely on stimulants — caffeine, guarana, taurine — that mask fatigue without addressing the underlying cause. R² Day targets mitochondrial efficiency directly. Mitochondrial function declines by roughly 8% per decade after age 30 (PLoS Biology, 2007), which means the cells themselves produce less energy as you age, regardless of how much coffee you drink. R² Day's Cordyceps Cs-4 has been studied for its effects on ATP production and oxygen utilisation in clinical trials (Chen S, et al., Journal of Alternative and Complementary Medicine, 2010;16(5):585-590).

The pomegranate extract is standardised for punicalagins and ellagic acid. Its metabolite, urolithin A, has been shown to induce mitophagy — the clearing of damaged mitochondria to make room for healthier ones (Ryu D, et al., Nature Medicine, 2016;22(8):879-888, PMID: 27400265). Alpha lipoic acid rounds out the formula as a dual-environment antioxidant that also functions as a cofactor in the mitochondrial energy chain.

Key Ingredients

Cordyceps sinensis Cs-4 — Standardised medicinal mushroom extract that supports ATP production. The Cs-4 strain is the same used in clinical research demonstrating improved exercise performance and oxygen utilisation in older adults over 12 weeks.

Pomegranate Extract — Provides punicalagins and ellagic acid, precursors to urolithin A, which supports mitophagy (clearance of damaged mitochondria). Standardised extract, not whole fruit powder.

Alpha Lipoic Acid — Works in both water-soluble and fat-soluble cellular environments. Functions as a mitochondrial cofactor in the pyruvate dehydrogenase complex and supports the recycling of vitamins C and E.

How to Use

Take 2 capsules in the morning with breakfast. The timing matters — R² Day is formulated for daytime metabolic patterns when mitochondrial energy demand is highest. Taking it in the evening is counterproductive. For best results, use alongside R² Night (sold separately or together in the R² pack at £109.00). Most users notice an energy difference within 2-4 weeks of consistent use. The effect is a sustained alertness rather than a spike — particularly noticeable during those grey British afternoons when you'd normally reach for the biscuit tin.

Who Is This For

Adults over 35 experiencing age-related energy decline — the kind where you're sleeping adequately but still flagging by mid-afternoon. Particularly relevant for desk workers in centrally heated offices where the combination of stale air and artificial light compounds fatigue. Not a stimulant, so it's suitable for people who are caffeine-sensitive or who've found that coffee no longer works as well as it used to. Not recommended for pregnant or breastfeeding women; consult your GP if you're on immunosuppressant medication.

Frequently Asked Questions

Can I buy R² Day separately without signing up?
Yes. NuBest Skin sells R² Day directly — no Nu Skin membership or account required. Ships from the official UK warehouse.

Do I need the Night formula as well?
R² Day works on its own for energy support, but the system is designed as a day-and-night pair. The Night formula handles detoxification and cellular repair during sleep, which complements the Day formula's energy focus. You'll get partial benefits from Day alone, but the full system delivers more comprehensive results.

How is this different from a B-vitamin energy supplement?
B-vitamins support energy metabolism as cofactors, but they don't directly address mitochondrial decline. R² Day targets the mitochondria themselves with Cordyceps and pomegranate extract — a fundamentally different mechanism. If you're already getting adequate B-vitamins from your diet or a multivitamin like LifePak+, adding more B-vitamins won't help. Addressing mitochondrial efficiency might.

Important Information

Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle. Do not exceed the recommended daily intake. Keep out of reach of young children. Store in a cool, dry place.

If you are pregnant, breastfeeding, taking medication, or under medical supervision, consult your GP before use.

NuBest Skin is an Independent Nu Skin Brand Affiliate. This website is independently operated and is not produced, endorsed, or approved by Nu Skin Enterprises, Inc.

Sources & References

• Chen S, et al. "Effect of Cs-4 on Exercise Performance in Healthy Older Subjects." Journal of Alternative and Complementary Medicine, 2010;16(5):585-590.
• Ryu D, et al. "Urolithin A induces mitophagy." Nature Medicine, 2016;22(8):879-888. PMID: 27400265.

Product information reviewed by the NuBest Skin Editorial Team. Last updated April 2026.