ageLOC Tru Face Essence Ultra (AU)

ageLOC Tru Face Essence Ultra is Nu Skin's flagship firming serum and remains one of the most clinically tested anti-ageing serums in the ageLOC range. In Nu Skin's own clinical trial, 100% of participants saw a visible reduction in fine lines after four weeks of twice-daily use, with 86% reporting firmer, more lifted skin. The formula centres on the Ethocyn compound — a patented ingredient shown to support the production of functional elastin, the protein responsible for skin's ability to snap back after stretching.

What Makes Tru Face Essence Ultra Different

Most firming serums target collagen exclusively. Tru Face Essence Ultra takes a different approach by focusing on elastin — the structural protein that gives skin its bounce and resilience. Elastin production naturally declines from your mid-20s, and by age 40, your skin retains roughly 50% of the elastin it had at 20 (International Journal of Cosmetic Science, 2019). The Ethocyn compound in this serum has been shown in laboratory studies to increase elastin production by up to 200%, addressing the root structural cause of sagging rather than masking it with temporary tightening agents.

The ageLOC blend targets gene expression clusters associated with skin ageing. Rather than treating individual symptoms, it works on the sources of ageing — the upstream processes that control how visibly your skin ages over time. Nu Skin's proprietary research identified specific Youth Gene Clusters, and the ageLOC technology is designed to reset these clusters to more youthful patterns of activity.

Key Ingredients

Ethocyn (ethoxylated ethyl cyanoacrylate): The cornerstone ingredient. Originally developed for wound-healing applications, Ethocyn was found to significantly boost functional elastin production. It's one of the few topical compounds with published data supporting genuine elastin synthesis rather than temporary firming effects.

Coenzyme Q10 (Ubiquinone): A naturally occurring antioxidant that decreases in the skin with age. At the concentration used in Tru Face Essence Ultra, CoQ10 provides cellular-level protection against oxidative stress — the kind of free radical damage that accelerates structural protein breakdown. Research published in BioFactors (2017) found that topical CoQ10 reduced wrinkle depth measurably in 12-week trials.

ageLOC blend: Nu Skin's proprietary complex of botanical and peptide ingredients designed to influence gene expression related to ageing. The specific composition targets the arNOX enzyme family, which plays a role in superoxide generation and cellular ageing.

How Australians Are Using Tru Face Essence Ultra

Australia's UV index regularly exceeds 11 — classified as "extreme" by the Bureau of Meteorology — for much of the year. This level of UV exposure accelerates elastin degradation faster than in most other markets. We've found that Australian users often pair Tru Face Essence Ultra with a broad-spectrum SPF 50+ sunscreen during the day, using the serum as an evening treatment to support repair while the skin is in its natural overnight recovery phase.

Apply two pumps to clean, dry skin after toning. Massage upward from jawline to forehead using firm, lifting strokes. Follow with your moisturiser. For best results, use both morning and evening — though if you're only using it once daily, evening application gives the Ethocyn compound uninterrupted hours to work alongside your skin's natural repair cycle.

How Does Tru Face Essence Ultra Compare?

Comparison based on publicly available product information as of April 2026. NuBest Skin is not affiliated with SkinCeuticals, Aspect, or Medik8.

Frequently Asked Questions

How long before I see results from Tru Face Essence Ultra?
Nu Skin's clinical data shows visible improvement in fine lines at four weeks with twice-daily use. Firming and lifting effects build progressively — most users report the most significant visible change between weeks four and eight.

Can I use Tru Face Essence Ultra with retinol?
Yes. The formula doesn't contain retinoids, so it layers well with retinol or retinal products. Apply your retinol first, wait two minutes for absorption, then apply Tru Face Essence Ultra. If you're using a strong retinol (0.5% or above), monitor for sensitivity during the first two weeks of combined use.

Is this suitable for sensitive skin?
The formula is fragrance-free and has been dermatologist-tested. That said, Ethocyn is an active compound — we always recommend a 24-hour patch test behind the ear before full facial application, particularly if you have reactive or rosacea-prone skin.

How does this differ from ageLOC Tru Face Future Serum?
Essence Ultra focuses primarily on elastin production via Ethocyn. Future Serum is a next-generation formula targeting fine lines and luminosity with retinol-like peptides and vitamin C derivatives. They address different aspects of ageing and can be used in the same routine — Essence Ultra in the evening, Future Serum in the morning.

One bottle lasts how long?
At two pumps twice daily, the 30ml bottle typically lasts 6–8 weeks depending on application volume. The refill pouch (ID 4770) offers the same formula with reduced packaging.

Important Information

Individual results may vary. This product is intended for cosmetic use only and is not designed to diagnose, treat, cure, or prevent any disease or skin condition. Discontinue use if irritation occurs and consult a dermatologist. Patch test recommended before first use.

Clinical results referenced are from studies conducted or commissioned by Nu Skin Enterprises, Inc. and may not reflect typical consumer experience.

NuBest Skin is an Independent Nu Skin Brand Affiliate. This website is independently operated and is not produced, endorsed, or approved by Nu Skin Enterprises, Inc.

Sources & References

1. Journal of Cosmetic Dermatology — Peer-reviewed research on peptide and elastin-targeting technologies in anti-ageing skincare.
2. Nu Skin ageLOC Science Overview — Published clinical data on ageLOC gene expression technology.
3. BioFactors (2017): Topical CoQ10 and Skin Ageing — Clinical evidence for Coenzyme Q10 efficacy in reducing wrinkle depth.
4. Skin Research and Technology — Scientific methodologies for measuring skin firmness and elasticity.
5. Australian Bureau of Meteorology — UV Index Data — UV exposure data referenced for Australian climate context.

Product information reviewed by the NuBest Skin Editorial Team. Last updated April 2026.