ageLOC® R² Night (Australia)

ageLOC R² Night is the overnight half of Nu Skin's R² day-and-night anti-ageing system, sold here as a standalone unit. It targets the body's natural overnight cellular purification using milk thistle (silymarin), broccoli seed extract (sulforaphane precursor), and curcumin. This listing is for customers who want to restock just the Night capsules, or trial the night formula on its own. If you intend to use the full circadian system long-term, the combined R² box (AU$155) is around AU$21 cheaper than buying Night (AU$88) and Day (AU$87.99) separately.

What R² Night Targets

The liver does most of its detoxification work overnight. Phase II detox enzymes — the ones responsible for conjugating and clearing toxins, drug metabolites, and oxidative stress byproducts — peak during sleep. Most antioxidant supplements ignore that timing entirely and dose everything at breakfast, when the liver's detox machinery is largely idle. R² Night times its actives to when the body is actually doing the work.

Milk thistle (silymarin) is one of the most extensively studied botanical hepatoprotectants available. A comprehensive review by Abenavoli L, et al. in Phytotherapy Research (2010;24(10):1423–1432) confirmed silymarin's hepatoprotective effects, including support for glutathione production — one of the body's primary detoxification molecules. Broccoli seed extract is rich in sulforaphane, which activates the Nrf2 pathway — essentially the master switch for endogenous antioxidant defence. Nrf2 activation upregulates phase II detoxification enzymes across the body, not just in the liver. Curcumin contributes additional anti-inflammatory and antioxidant support.

How It Differs from R² Day

R² Night and R² Day are not interchangeable — each formula targets the biological phase it's named for. Night supports the liver's overnight phase II detoxification and the Nrf2 antioxidant pathway, both of which are most active during sleep. Day uses Cordyceps Cs-4, pomegranate, and chokeberry to support mitochondrial ATP production for the active waking hours. The full circadian benefit only materialises when both halves run together; that's the design rationale for the system. Read the R² Hub page for the complete explanation of why the day/night split matters.

How Australians Are Using R² Night

Take the daily dose with the evening meal or roughly 30 minutes before bed. Curcumin and broccoli seed extract are fat-soluble and absorb significantly better with a small amount of dietary fat — taking on an empty stomach wastes a portion of the formula. Some customers use R² Night as a standalone after periods of dietary indulgence (long weekends, travel, end of a project sprint) to support the liver's increased detox workload. Others use it consistently as the overnight half of the full R² protocol. The ingredients are gentle enough for daily long-term use.

Frequently Asked Questions

Can I take R² Night without R² Day?
Yes. R² Night works independently for overnight cellular purification and antioxidant pathway support. You won't get the daytime energy benefits the Day formula delivers, but the Night formula functions on its own.

Will R² Night make me drowsy?
No. R² Night doesn't contain melatonin, valerian, or any sedative ingredients. It's taken at night because that's when the liver's phase II detoxification enzymes are most active — not because the product induces sleep. You can take it in the evening without concern about drowsiness.

Is this the same product that comes in the combined R² box?
Yes — identical formula. The standalone R² Night is the same milk thistle / broccoli seed / curcumin capsule that ships in the combined R² box. The standalone exists for restocks and single-formula trials.

Can I take R² Night with prescription medication?
Silymarin can mildly affect the metabolism of certain medications via cytochrome P450 pathways. If you take prescription medication — particularly anticoagulants (warfarin), immunosuppressants (cyclosporine, tacrolimus), or drugs with a narrow therapeutic window — consult your healthcare professional or pharmacist before starting R² Night.

Works With

R² Day — the daytime half of the system. Run them together for the full circadian protocol. The combined R² box bundles both at AU$155 (saves around AU$21 vs separate purchase).

Important Information

Always read the label and follow the directions for use. Supplements should not replace a balanced diet. If symptoms persist, consult your healthcare professional. Not suitable for children under 15 years unless advised by a healthcare practitioner. If you are pregnant, breastfeeding, or taking prescription medication (particularly anticoagulants, immunosuppressants, or drugs metabolised through cytochrome P450 pathways), consult your doctor before use. This information is provided for educational purposes only and does not constitute medical advice.

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Product information reviewed by the NuBest Skin Editorial Team. Last updated April 2026.