Nu Biome® Gut Health Formula (U.S)

Pharmanex® Nu Biome® — Clinically Proven Gut Health Support, One Stick Pack a Day

Your gut does a lot more than digest food. The trillions of microorganisms living in your gastrointestinal tract — collectively your gut microbiome — influence your immune function, energy levels, antioxidant defence, and overall sense of wellbeing. When that microbial balance shifts, the effects show up in ways that go well beyond your stomach: bloating, digestive discomfort, low energy, and a general feeling of being off.

Pharmanex® Nu Biome® was formulated to address this directly — not with live probiotic cultures that face an uphill battle surviving stomach acid, but with a targeted dual-action approach combining a clinically effective prebiotic (XOS) and a clinically studied postbiotic (heat-treated BPL1). Add in pomegranate extract for antioxidant support and a healthy caffeine boost, and you have a daily gut health ritual that's both scientifically grounded and genuinely easy to stick to — in a watermelon lemon raspberry flavored powder stick that mixes into any beverage in seconds.*

Clinically Proven Results — The Numbers Speak for Themselves

Nu Skin commissioned a rigorous clinical study involving 50 healthy men and women who took either Nu Biome or a placebo daily for four weeks. Waist circumference was measured as an objective marker of bloating before and after a standardised challenge meal. The results were striking:*

• ✔ 100% of participants experienced a significant reduction in waist circumference (average 2.4cm / 0.9in) from bloating after just one use*
• ✔ 93% experienced a continued significant reduction (5.5cm / 2.2in) from bloating after four weeks*
• ✔ 82% felt a reduction in bloating*
• ✔ 86% felt less bloated after meals*
• ✔ 82% experienced less digestive discomfort*
• ✔ 75% agreed Nu Biome calmed their bloating quickly — within one hour*
• ✔ 64% reduction in abdominal discomfort after four weeks*
• ✔ 65% reduction in bloating frequency after four weeks*

These are not self-reported impressions — they are objective, clinically measured outcomes from a controlled study design, making Nu Biome one of the most rigorously validated gut health supplements available over the counter.*

Key Benefits

• ✔ Supports quick and effective reduction in bloating after meals*
• ✔ Supports waist circumference reduction related to bloating*
• ✔ Provides continual improvement in bloating relief with consistent use*
• ✔ Promotes beneficial bacteria in the gut*
• ✔ Supports a healthy balance of good and bad bacteria for improved intestinal health*
• ✔ Helps maintain healthy digestion*
• ✔ Supports regularity with consistent daily use*
• ✔ Supports your body's important antioxidant network*
• ✔ Supports healthy energy†
• ✔ Free from artificial colors, flavors, and sweeteners
• ✔ 30 stick packs per bag — one per day

The Science: Why Pre AND Postbiotics Together

Most gut health supplements focus on one approach. Nu Biome uses two complementary mechanisms simultaneously — and the distinction matters.

Prebiotics are non-digestible nutrients that feed and fuel beneficial bacteria in your gut. Think of them as fertilizer for your microbiome's good bacteria — selectively nourishing them to thrive and outcompete less beneficial strains. Because most Americans don't get sufficient prebiotic fiber from diet alone, targeted supplementation can make a meaningful difference.*

Postbiotics are a newer, cutting-edge area of gut health research — focused not on live bacteria, but on the beneficial compounds those bacteria produce. Nu Biome's postbiotic is a heat-treated bacterium (BPL1): the bacteria are no longer alive, but the beneficial substances they produced are preserved and delivered directly. This approach bypasses the survival challenge live probiotics face in stomach acid — delivering consistent, reliable gut support every time.*

Together, these two mechanisms support your gut microbiome from two distinct but complementary directions — fuelling beneficial bacteria while simultaneously delivering their beneficial compounds directly.*

Key Ingredients

• XOS (Xylooligosaccharides) — a clinically effective prebiotic that promotes beneficial bacteria in the gut to support a healthy microbiome. XOS is selectively fermented by beneficial bacterial strains, giving them a competitive advantage in your intestinal environment*
• Heat-Treated BPL1 (Bifidobacterium lactis BPL1) — a clinically studied postbiotic that delivers the beneficial compounds produced by intestinal bacteria in a stable, reliable form. The heat treatment preserves bioactive compounds while eliminating the need for live culture survival*
• Caffeine — a healthy source of energy, complementing your other daily caffeine sources†
• Pomegranate Extract — a standardised whole fruit extract providing a high concentration of polyphenols to support antioxidant defense against oxidative stressors*

Other Ingredients: Citric Acid, Natural Flavors (Raspberry, Watermelon, Lemonade), Beet Root (for color), Stevia Rebaudioside A (from Stevia rebaudiana Leaf Extract), Guar Gum, Acacia Gum, Xanthan Gum, Sea Salt.

How Pharmanex® Nu Biome® Compares to Other Gut Health Supplements in the US

The gut health supplement market in the United States is one of the fastest-growing supplement categories — but most products take a narrow, single-mechanism approach. Here's how Nu Biome compares to some of the most widely available options:

Feature	Pharmanex® Nu Biome®	Culturelle Digestive Daily	Ritual Synbiotic+	Seed DS-01 Daily Synbiotic	Garden of Life Raw Probiotics
Approach	Dual pre + postbiotic (XOS + BPL1)	Single-strain probiotic (LGG)	Pre + pro + postbiotic	24-strain probiotic blend	Multi-strain probiotic
Clinically Studied Formula	✔ Nu Skin-commissioned 4-week RCT (50 subjects)	✔ LGG strain studies	Ingredient-level studies	Ingredient-level studies	Ingredient-level studies
Bloating Reduction	✔ 100% waist reduction after one use (clinical)*	General digestive support	General digestive support	General digestive support	General digestive support
Postbiotic Included	✔ Heat-treated BPL1	✗ Not included	✔ Postbiotic included	✗ Not included	✗ Not included
Prebiotic Included	✔ XOS (clinically effective)	✗ Not included	✔ Prebiotic included	✔ Prebiotic included	✗ Not included
Antioxidant Support	✔ Pomegranate extract (polyphenols)*	✗ Not included	✗ Not included	✗ Not included	✗ Not included
Energy Support	✔ Natural caffeine†	✗ Not included	✗ Not included	✗ Not included	✗ Not included
Format	Powder stick pack — mixes into any beverage	Capsule	Capsule	Capsule	Capsule / powder
Artificial Additives	✔ Free from artificial colors, flavors & sweeteners	Contains some additives	Clean label	Clean label	Minimal additives
Refrigeration Required	✔ No refrigeration needed	Recommended	✔ No refrigeration	✔ No refrigeration	Recommended

What separates Nu Biome from most gut health supplements on the US market is the clinical evidence — specifically, the 100% response rate for bloating reduction after a single use, measured objectively by waist circumference in a controlled study. Most competitors rely on strain-level research that doesn't directly translate to the specific formula in the bottle. Nu Biome's clinical evidence is on the actual product.*

How to Use

Mix one stick pack with 250–300ml of water or your favorite beverage. Enjoy once daily. Best taken consistently for maximum benefit — the clinical study showed continued improvement over four weeks of daily use.*

Contains caffeine. Not recommended for children or those sensitive to caffeine. Consult your physician before use if you are pregnant, breastfeeding, or taking prescription medication.

Frequently Asked Questions

What is bloating exactly?
Bloating is a digestive issue that causes your stomach to feel full, tight, and/or uncomfortable. It may be accompanied by abdominal distension (measured as an increase in waist circumference), gas, and fluid retention. It's one of the most common digestive complaints in the United States — and one that Nu Biome's formula directly addresses.*

How quickly does Nu Biome work for bloating?
In the clinical study, 100% of participants experienced a measurable reduction in waist circumference from bloating after just one use. 75% reported feeling bloating relief within one hour. With consistent daily use over four weeks, 93% experienced continued significant reduction in bloating.*

Will Nu Biome help me lose weight?
No. Nu Biome is designed to support gut health and reduce bloating — not to cause weight loss, fat loss, or a reduction in waist circumference unrelated to bloating. While the clinical study measured waist circumference as a marker of bloating, this should not be interpreted as a weight loss effect.*

What is my gut microbiome?
Your gut microbiome includes all the microorganisms — bacteria, fungi, and other microbes — living inside your gastrointestinal tract. There are trillions of them, outnumbering your actual human cells. Some are beneficial, some are less so, and maintaining the right balance is what drives healthy digestion, immune function, and overall wellbeing. Nu Biome supports that balance from two angles.*

What's the difference between a prebiotic and a postbiotic?
Prebiotics (like XOS in Nu Biome) are non-digestible nutrients that feed beneficial bacteria — like fertilizer for your gut's good microbes. Postbiotics (like heat-treated BPL1 in Nu Biome) are the beneficial compounds produced by bacteria — delivered directly, without relying on live cultures. Together, they support your microbiome through two complementary mechanisms that work better in combination than either alone.*

Can I take Nu Biome with other Pharmanex gut health products?
Yes. Nu Biome works well alongside Nu Ease (upper and lower GI discomfort relief, especially after heavy meals) and ProBio PCC (a live probiotic shown to colonise in the gut). Each targets different aspects of digestive health and they can be taken individually or together for more comprehensive gut support.*

How much caffeine is in Nu Biome?
Nu Biome contains a modest amount of caffeine as a healthy energy source, intended to complement your other daily caffeine intake rather than replace it. If you are sensitive to caffeine, consider taking Nu Biome earlier in the day. A caffeine-free version (Nu Biome Caffeine Free) is also available if you prefer to avoid caffeine entirely.†

Is Nu Biome suitable for vegans?
The active ingredients in Nu Biome are microbial or plant-derived. For specific vegan suitability confirmation, please check the current product label or contact Nu Skin customer support, as formulations can be updated.

Why doesn't Nu Biome use live probiotics?
Live probiotics face a significant challenge: surviving the acidic environment of the stomach to reach the intestine. Heat-treated postbiotics like BPL1 deliver the beneficial compounds of bacteria without this survival challenge — providing consistent, reliable gut support regardless of stomach acid levels. This is one reason Nu Biome's clinical results are so consistent across participants.*

Can I mix Nu Biome with something other than water?
Yes — Nu Biome mixes well into any cold beverage: juice, a smoothie, sparkling water, or an iced tea. Avoid mixing with very hot liquids, as heat may affect the postbiotic compounds.

Authoritative References

• American Gastroenterological Association — The Gut Microbiome
• Postbiotics: An Evolving Term Within the Functional Foods Field — Trends in Food Science & Technology
• Xylooligosaccharides and gut microbiota modulation — Nutrients
• Pomegranate polyphenols and gut microbiota — Advances in Nutrition
• National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) — Your Digestive System

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. †Nu Biome (original) only. Not applicable for Nu Biome Caffeine Free.