ageLOC® R2 Night + Day (USA)

ageLOC® R2 Night + Day — The Complete 24-Hour Cellular Renewal System

Your body operates on a natural cycle: repair and purify during sleep, produce energy and perform during the day. ageLOC® R2 is the first supplement system designed to work with both phases of this cycle simultaneously. The Night formula supports cellular purification while you sleep — helping your cells clear accumulated metabolic waste. The Day formula promotes cellular energy production when you wake — supporting mitochondrial ATP generation for sustained vitality. Together, they create an unbroken loop of cellular support: purify, recharge, repeat.

This bundle combines both formulas in a single purchase — one month's supply of the complete R2 system. It's the most popular way to buy R2, and for good reason: Nu Skin's research indicates that the purification and energy production pathways are interdependent. Cells that are efficiently purified at night produce energy more efficiently during the day. Cells that produce clean energy during the day generate less waste for nighttime cleanup. The two halves amplify each other.

Key Benefits

• 24-Hour Cellular Support — Continuous gene expression support through both phases of the cell cycle: overnight purification (Night) and daytime energy production (Day). No gap in cellular support
• Youth Gene Cluster Targeting — Both formulas target specific gene clusters identified through Nu Skin's genomics research. Night targets purification-related genes; Day targets energy-related genes. Together, they address a broader range of aging-related gene expression changes than either formula alone
• Amplified Results — The purify-recharge cycle is self-reinforcing: better nighttime purification leads to more efficient daytime energy production, which generates less cellular waste, which makes nighttime purification more effective. Users of both formulas report stronger benefits than users of either alone
• Adaptogenic Support — Cordyceps sinensis appears in both formulas, providing round-the-clock adaptogenic support. Panax ginseng in the Day formula adds daytime-specific endurance and cognitive support
• Stimulant-Free Energy — The Day formula contains no caffeine or stimulants. Energy improvements come from improved cellular energy production, not nervous system stimulation

What's Included

• ageLOC R2 Night (30-day supply) — Evening formula with the proprietary ageLOC blend, Cordyceps Cs-4, Pomegranate Extract, and Alpha-Lipoic Acid. Take before bed to support cellular purification during sleep
• ageLOC R2 Day (30-day supply) — Morning formula with the proprietary ageLOC blend, Cordyceps Cs-4, Panax Ginseng, and Pomegranate Extract. Take with breakfast to support cellular energy production throughout the day

Key Ingredients

Both formulas share a core ingredient foundation but are differentiated by additional compounds selected for their specific phase-appropriate benefits.

• Proprietary ageLOC Blend (Both Formulas) — The core of the R2 system. Targets Youth Gene Clusters identified through Nu Skin's genomic profiling research — genes whose expression patterns change predictably with aging. The Night version targets purification-related genes; the Day version targets energy production-related genes. Same technology, different gene targets
• Cordyceps Sinensis Cs-4 (Both Formulas) — Present in both Night and Day for continuous adaptogenic support. During sleep, cordyceps supports cellular oxygen utilization during repair processes. During the day, it enhances physical stamina and exercise performance. The Cs-4 strain is specifically cultivated for consistent bioactive compound levels
• Panax Ginseng (Day Only) — Provides daytime-specific support for physical endurance, mental alertness, and stress resilience. Over 2,000 published studies support ginseng's benefits for cognitive performance and physical vitality. Not included in the Night formula because its stimulating properties are inappropriate for the sleep phase
• Pomegranate Extract (Both Formulas) — Delivers punicalagins that support mitochondrial recycling (mitophagy) and cardiovascular health. During sleep, this supports cellular cleanup; during the day, it supports circulatory efficiency for nutrient delivery
• Alpha-Lipoic Acid (Night Only) — A dual-environment antioxidant that works in both water and fat environments within cells, providing comprehensive protection during the overnight repair window

How Nu Skin's Approach Differs

The supplement industry typically treats anti-aging as a single problem with a single solution: take one daily pill with antioxidants and hope for the best. Nu Skin recognized that cellular aging involves multiple distinct processes that occur on a schedule — purification systems are most active during sleep, energy production systems dominate during waking hours. R2 is designed around this biological reality.

The genomics-based formulation is another key differentiator. Rather than selecting ingredients based on marketing trends or basic nutritional theory, Nu Skin's research team identified the specific gene clusters whose declining expression drives age-related changes in cellular function. Each R2 ingredient was selected for its documented ability to influence these specific gene clusters toward more youthful expression patterns.

This systems-based, genomics-driven approach is substantiated through the 6S Quality Process. Every ingredient is selected based on genomic research, sourced from verified suppliers, structured for optimal bioactivity, standardized for potency, safety-tested, and substantiated through both in-vitro and clinical validation.

How It Compares

Comparison based on publicly available product information as of 2025. Features and formulations may change.

How to Use

Evening: Take R2 Night capsules 30-60 minutes before bed with water. Morning: Take R2 Day capsules with breakfast. Consistency is everything — the gene expression benefits compound over weeks of regular use. Most people notice improved morning energy within 2-4 weeks. This bundle provides a full 30-day supply of both formulas.

Who Should Consider This Product

The R2 bundle is ideal for adults 30+ who want comprehensive cellular anti-aging support without complexity. If you've tried individual anti-aging supplements and found the results underwhelming, the dual-phase approach may be worth trying — it addresses a broader range of aging-related gene expression changes than single-formula products. Also well-suited for those interested in the science of gene expression and aging rather than just general supplement usage. Not recommended during pregnancy or while nursing. Consult your healthcare provider if you're on blood pressure medication or immunosuppressants.

Frequently Asked Questions

Q: Why is the bundle better than buying Night and Day separately?

A: Beyond convenience, the biological case is strong: the purification (Night) and energy production (Day) pathways are interdependent. Cells that purify efficiently at night produce energy more efficiently during the day, and vice versa. Using both creates a self-reinforcing cycle that delivers stronger results than either formula alone.

Q: I'm already taking NMN/NAD+ supplements. Can I use R2 alongside them?

A: There's no known negative interaction. R2 targets gene expression patterns while NMN/NAD+ supplements target the NAD+ coenzyme pathway. They work through different mechanisms and could theoretically complement each other, though no specific studies exist on the combination.

Q: How does R2 fit with the rest of the ageLOC supplement line (Meta, Youth)?

A: R2 focuses on cellular purification and energy. Meta targets metabolic health and gut microbiome. Youth (Y-Span) provides broad anti-aging support across multiple aging pathways. They're designed as complementary products, each addressing different aspects of aging without significant ingredient overlap.

Q: How long does one bundle last?

A: 30 days — one month's supply of both Night and Day formulas at the recommended daily dose.

Q: Are there any side effects I should watch for?

A: R2 is generally well-tolerated. The most common initial experience is mild digestive adjustment during the first few days. If you have mushroom allergies, avoid this product due to the cordyceps content. The ginseng in R2 Day may interact with blood pressure medications and blood thinners — consult your doctor if applicable.

Shipping & Payment

Payment Methods: Credit Card, Apple Pay, Google Pay, PayPal, PayPal Pay Later

Shipping: US-wide delivery, typically 3-7 business days

Shipping Cost: US$2.99 flat rate

Free Shipping: On orders over US$79

References

• PubMed — Urolithin A Induces Mitophagy and Prolongs Lifespan (Nature Medicine, 2016)
• PubMed — Pharmacological and Therapeutic Potential of Cordyceps (2011)
• PubMed — Effects of Panax Ginseng on Cognitive Function: A Meta-Analysis (2018)
• Nu Skin Official — ageLOC R2 Product Page

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

NuBest Skin is an independent Nu Skin Brand Affiliate. This product listing is not produced or endorsed by Nu Skin Enterprises, Inc.