TRME INNERNu (UK)

TRME INNERNu is a daily gut health sachet combining prebiotics and postbiotics to support the gut-metabolism connection — the bidirectional communication between your gut microbiome and metabolic processes that influences how efficiently your body handles energy from food. At £28.50 for a 30-day supply, it's the gut health component of the TRME weight management system, though it works independently for anyone focused purely on digestive wellness. The growing body of research linking gut microbiome composition to metabolic outcomes is substantial — a 2016 paper in Nature (Sonnenburg JL, Bäckhed F, 2016;535(7610):56-64) established that gut bacteria composition directly influences energy harvest from food, fat storage signalling, and appetite-regulating hormones.

What Makes INNERNu Different

Most gut health supplements provide either probiotics (live bacteria) or prebiotics (fibre to feed bacteria). INNERNu includes both prebiotics and postbiotics — the bioactive metabolites produced by beneficial bacteria. Postbiotics are a relatively recent area of nutritional science, and the evidence for their direct metabolic effects is growing. The advantage of postbiotics over probiotics is stability: they don't require refrigeration, aren't killed by stomach acid, and their effects are more consistent because you're delivering the active compounds directly rather than hoping live bacteria survive and produce them in sufficient quantities.

The formulation is designed specifically for the gut-metabolism axis rather than general digestive health. While products like Symprove and Optibac focus on gut comfort and bacterial diversity, INNERNu targets the metabolic dimension — supporting the microbiome environment that enables efficient nutrient processing and healthy weight management. It's a more specific product with a more specific purpose.

Key Ingredients

Prebiotic Fibre Complex — Feeds beneficial gut bacteria (particularly Bifidobacterium and Lactobacillus species) to promote microbiome diversity. Diverse gut microbiomes are consistently associated with healthier metabolic outcomes in population studies.

Postbiotic Compounds — Bioactive metabolites including short-chain fatty acids (SCFAs) and other bacterial products that have direct effects on gut barrier integrity, immune signalling, and metabolic regulation. SCFAs like butyrate support the integrity of the intestinal lining and influence appetite hormones.

Soluble Fibre — Provides bulk and supports transit time, but also acts as a fermentation substrate for beneficial bacteria, promoting SCFA production in the colon.

How to Use

Mix one sachet daily with water or a cold beverage, preferably in the morning. The powder dissolves easily and has a mild, slightly sweet flavour. As part of the full TRME system, take INNERNu alongside MyEDGE, MyGOAL, and REALMe. As a standalone gut health product, one sachet daily provides meaningful prebiotic and postbiotic support. Initial digestive adjustment (mild bloating or changed bowel habits) is normal in the first 3-5 days as the gut microbiome responds to increased prebiotic intake — this typically resolves quickly.

Who Is This For

Anyone interested in the gut-metabolism connection, particularly as part of a weight management approach. Also suited for people wanting targeted gut support that goes beyond basic probiotics — the postbiotic component provides a more direct metabolic benefit. Useful for people who've tried probiotics like Symprove or Yakult and want to add prebiotic and postbiotic support. Not a treatment for diagnosed IBS, IBD, or other gut conditions — consult your GP for those.

Frequently Asked Questions

Can I buy INNERNu without signing up?
Yes. NuBest Skin sells it directly — no membership or account needed. Ships from the official UK warehouse.

Do I need to take the whole TRME system, or does this work alone?
INNERNu works independently as a daily gut health supplement. The full TRME system (MyEDGE + MyGOAL + REALMe + INNERNu) provides more comprehensive weight management support, but INNERNu's gut health benefits don't depend on the other products.

How is this different from Symprove or Yakult?
Symprove and Yakult are probiotic products — they deliver live bacteria. INNERNu provides prebiotics (food for your existing bacteria) and postbiotics (the beneficial compounds bacteria produce). They work through different mechanisms and can be complementary rather than competing.

Important Information

Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle. Do not exceed the recommended daily intake. Keep out of reach of young children. Store in a cool, dry place.

If you are pregnant, breastfeeding, taking medication, or under medical supervision, consult your GP before use.

NuBest Skin is an Independent Nu Skin Brand Affiliate. This website is independently operated and is not produced, endorsed, or approved by Nu Skin Enterprises, Inc.

Sources & References

• Sonnenburg JL, Bäckhed F. "Diet-microbiota interactions as moderators of human metabolism." Nature, 2016;535(7610):56-64.
• Nu Skin Enterprises. TRME INNERNu product documentation.

Product information reviewed by the NuBest Skin Editorial Team. Last updated April 2026.