ageLOC® R² (R2) Night (Ireland/EU)

ageLOC R² Night is the evening component of Nu Skin's dual anti-ageing supplement system, designed to support your body's natural cellular purification and renewal processes during sleep. The formula targets Youth Gene Clusters associated with nocturnal detoxification and repair, using milk thistle, resveratrol, and wasabi extract. If you're waking up feeling unrested despite adequate sleep hours — something many Irish adults experience during the long winter — R² Night supports the quality of what happens at the cellular level while you're asleep.

What Sets R² Night Apart

Your body does its most intensive repair work during sleep: cellular waste removal, DNA repair, immune consolidation, and tissue regeneration. R² Night's formula is timed to support these processes. Milk thistle (silymarin) has centuries of documented use in supporting liver function and cellular protection — relevant because the liver's detoxification activity peaks during sleep. Resveratrol activates SIRT1, a protein linked to cellular longevity and DNA repair. Wasabi extract provides isothiocyanates that support phase II detoxification enzymes.

Ireland's generally cool bedroom temperatures and quieter nighttime environment (compared to warmer, noisier urban climates) already support good sleep conditions. R² Night works with these advantages by ensuring the cellular processes that happen during those sleep hours are functioning optimally.

Key Ingredients

Milk Thistle Extract (Silymarin): One of the most researched botanical extracts for liver support and cellular protection. Supports the liver's natural detoxification processes, which peak during sleep hours.

Resveratrol: A polyphenol from red grape skin that activates SIRT1 — a protein associated with DNA repair, cellular longevity, and metabolic regulation. Research by Baur & Sinclair (2006, Nature Reviews Drug Discovery) documented its therapeutic potential.

Wasabi Extract: Contains long-chain isothiocyanates that support phase II detoxification enzymes. Works through a different mechanism than broccoli-sourced isothiocyanates found in R² Day, providing complementary detoxification support.

How to Get the Most from R² Night

Take the recommended dose in the evening, ideally 30–60 minutes before bed. Consistency is important — the gene expression effects build over time with daily use. Don't take R² Night in the morning; its formula is specifically designed to complement nocturnal biological processes.

For best results, maintain good sleep hygiene: keep your bedroom cool (Ireland's climate helps here), limit screen exposure before bed, and aim for 7–9 hours of sleep. R² Night enhances what your body does during sleep — it's not a sleep aid and doesn't cause drowsiness.

R² Night is designed to pair with R² Day for a complete anti-ageing system: Day supports energy and vitality during waking hours, Night supports purification and renewal during sleep. Both are available separately, but the combined system targets the full 24-hour cycle of age-related gene expression.

Frequently Asked Questions

Can I get R² Night delivered in Ireland?

Yes — ships to anywhere in Ireland, including Northern Ireland, typically within 3–5 working days.

Is R² Night a sleep aid?

No. R² Night doesn't cause drowsiness or contain melatonin. It supports cellular repair and purification processes that naturally occur during sleep — it doesn't induce sleep itself.

Can I take R² Night without R² Day?

Yes, it works independently. However, the full R² system is designed as a paired Day + Night approach for comprehensive anti-ageing support across the full 24-hour cycle.

Important Information

Food supplement. Do not exceed the recommended daily intake. Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle. Keep out of reach of young children. If you are pregnant, breastfeeding, taking any medication, or under medical supervision, consult your GP or healthcare professional before use.

This information is provided for educational purposes only and does not constitute medical advice. Individual results may vary.

NuBest Skin is an Independent Nu Skin Brand Affiliate. This website is independently operated and is not produced, endorsed, or approved by Nu Skin Enterprises, Inc.

Sources & References

1. Nu Skin Enterprises, Inc. — ageLOC R² Night Official Product Information, nuskin.com
2. Baur, J.A. & Sinclair, D.A. (2006) — "Therapeutic potential of resveratrol," Nature Reviews Drug Discovery, 5, 493–506
3. Abenavoli, L. et al. (2018) — "Milk thistle in liver diseases," Phytotherapy Research, 32(11), 2202–2213

Product information reviewed by the NuBest Skin Editorial Team. Last updated April 2026.