Estera® Phase II Women's Transitions Formula (U.S Only)

Product Overview

Estera® Phase II Women's Transitions Formula is a dietary supplement developed specifically for women navigating perimenopause and menopause. It belongs to Nu Skin's Estera® wellness line, formulated to address hormonal fluctuations through a blend of standardized botanical extracts and phytoestrogens — plant-derived compounds that interact with the body's oestrogen receptors. The formula targets common transitional symptoms including hot flashes, night sweats, occasional irregular bleeding, mild mood swings, and anxiousness. Unlike hormone replacement therapies, Estera® Phase II works through plant-based mechanisms to support a healthy oestrogen metabolite balance. Ships from official Nu Skin warehouse through local NuBest stores worldwide.

Key Ingredients & Science

Each capsule delivers a precisely standardized blend of botanicals with documented hormonal-support activity:

• Red Clover Extract (Trifolium pratense, 30:1) — 80 mg, equivalent to 2.4 g dry flowering herb. A rich source of isoflavones (formononetin, biochanin A) that bind oestrogenic receptors, with clinical evidence supporting reduction of hot flash frequency.
• Flaxseed Extract (Linum usitatissimum, 8:1) — Equivalent to 1.2 g dry seed coat, standardized for secoisolariciresinol lignans. Lignans are metabolized by intestinal microflora into enterolactone and enterodiol, which modulate oestrogen metabolism in the liver toward favorable 2-hydroxyoestrone pathways.
• Broccoli Powder (Brassica oleracea var. botrytis) — 150 mg flowering herb top powder, providing indole-3-carbinol (I3C). I3C promotes a healthy ratio of oestrogen metabolites by upregulating CYP1A1 hepatic enzyme activity.
• Pomegranate Extract (Punica granatum, 55:1) — 40 mg, equivalent to 2.2 g fresh fruit. Contains ellagitannins and phytooestrogens that complement isoflavone activity at receptor sites.

The synergistic combination of phytoestrogens and lignan-based hepatic oestrogen modulation is the core scientific rationale for this formula's dual-action approach.

How to Use

Take one capsule per serving, as directed by a healthcare professional or per the product label. Consistent daily use is recommended for cumulative benefit. Estera® Phase II is designed to complement a balanced diet and may be incorporated alongside other Nu Skin nutritional supplements. Consult a healthcare provider before use, particularly if taking medications or managing hormonal conditions.

Frequently Asked Questions

What is Estera® Phase II Women's Transitions Formula?

Estera® Phase II is a botanical dietary supplement formulated to support women during perimenopause and menopause. It combines standardized phytoestrogens, flaxseed lignans, broccoli-derived indole-3-carbinol, and pomegranate extract to help manage hormonal transitions and relieve associated symptoms such as hot flashes and night sweats.

What are the key active ingredients in Estera® Phase II?

The primary actives are Red Clover extract (standardized isoflavones), Flaxseed extract (secoisolariciresinol lignans), Broccoli powder (indole-3-carbinol), and Pomegranate extract. Each ingredient targets oestrogen receptor activity or hepatic oestrogen metabolism from a distinct biochemical angle.

How does Estera® Phase II work?

Phytoestrogens in the formula bind to the body's oestrogen receptors, partially mimicking oestrogen's effects. Simultaneously, flaxseed lignans and I3C from broccoli support the liver's ability to metabolize oestrogen into healthier, less proliferative metabolite forms, creating a two-pathway approach to hormonal balance.

How does Estera® Phase II fit into a daily supplement routine?

It is intended as a daily supplement taken consistently over time. It can be used alongside general nutritional supplements. Women in early perimenopause are encouraged to begin use proactively, as phytoestrogen intake from an early stage may provide longer-term benefits for bone strength and cardiovascular health.

What results can I expect and in what timeframe?

Clinical studies on isoflavone-rich botanical supplements generally show measurable reduction in hot flash frequency and severity within 8–12 weeks of consistent use. Individual responses vary based on gut microbiome composition, which influences lignan and isoflavone conversion rates.

Available Worldwide

This product is available through NuBest Skin in 37 countries worldwide. Visit your local NuBest store for pricing, availability, and country-specific product information.

NuBest Skin is an Independent Nu Skin Brand Affiliate. This website is independently operated and is not produced, endorsed, or approved by Nu Skin Enterprises, Inc.

This product is a dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease. Regulations vary by country — check your local NuBest store for country-specific compliance information.