ageLOC® R² Night (Australia)

ageLOC® R² Night — Cellular Purification While You Sleep

Every day, your cells accumulate waste. Metabolic by-products, environmental toxins, and the natural debris of cellular activity build up over time — and if not efficiently cleared, this accumulation contributes to the cellular decline we associate with ageing. The good news: your body already has sophisticated purification mechanisms designed to handle exactly this. The question is whether those mechanisms are being adequately supported.

ageLOC® R² Night is formulated to do precisely that. Taken in the evening, it works in alignment with your body's natural overnight renewal cycle — optimising each cell's purification processes so that waste and toxic by-products are more effectively neutralised and removed. The result: waking up feeling genuinely refreshed, with cells that have had the support they need to start the next day in better condition.*

Why Nighttime Is the Right Time

Your body's cellular repair and detoxification processes are most active during sleep. This is when the brain clears metabolic waste through the glymphatic system, when tissues repair, and when cellular housekeeping — including autophagy, the process by which cells break down and recycle damaged components — operates at its peak. ageLOC® R² Night is specifically formulated for evening use to align with and support these natural biological rhythms, rather than working against the body's own timing.*

Key Benefits

• ✔ Optimises each cell's natural purification process*
• ✔ Supports the body's ability to neutralise and remove cellular waste and toxic by-products*
• ✔ Helps protect and fortify cells against damage from external toxins by supporting the body's own protective mechanisms*
• ✔ Supports normal cellular detoxification processes*
• ✔ Helps you start each day feeling refreshed and renewed*
• ✔ Targets ageing at its cellular source — not just visible symptoms*

Key Ingredients

• Grape Seed Extract (Vitis vinifera L.) — one of the most studied natural antioxidants, grape seed extract is rich in oligomeric proanthocyanidins (OPCs) — potent compounds that support cellular protection against oxidative damage and help fortify the body's natural defence mechanisms*
• Red Orange Extract (Citrus sinensis) — sourced from the distinctive blood oranges of Sicily, red orange extract is rich in anthocyanins and hydroxycinnamic acids with documented antioxidant and cellular protective properties, supporting the body's defences against environmental toxin damage*
• Broccoli Seed Extract (Brassica oleracea italica) — a concentrated source of glucoraphanin, the precursor to sulforaphane — one of the most researched natural activators of the body's own detoxification enzyme systems. Broccoli seed extract supports the body's internal protective pathways at a cellular level*

Other Ingredients: Capsule (Gelatin), Microcrystalline Cellulose, Stearic Acid, Silicon Dioxide.

How ageLOC® R² Night Compares to Other Cellular Health Supplements in Australia

Cellular detoxification and overnight recovery supplements represent a growing category in the Australian market. Here's how ageLOC® R² Night compares to some of the most recognised options available:

Feature	ageLOC® R² Night	Swisse Ultiboost Liver Detox	Blackmores Antioxidant	Bioceuticals Resveratrol 125	Nutra-Life Grape Seed 12000
Primary Approach	Cellular purification — neutralise + remove waste*	Liver detox herbs	General antioxidant defence	Resveratrol longevity support	OPC antioxidant support
Cellular Detoxification	✔ Direct cellular focus*	Organ-level (liver only)	Indirect via antioxidants	Partial via sirtuin pathways	Indirect via antioxidants
Detox Enzyme Activation	✔ Broccoli seed / sulforaphane pathway*	Milk thistle / St Mary's thistle	✗ Not targeted	✗ Not targeted	✗ Not targeted
Cellular Protection	✔ Grape seed + red orange dual antioxidants*	Partial via artichoke	✔ Broad antioxidant blend	✔ Resveratrol focused	✔ OPC focused
Overnight Formulation	✔ Specifically designed for evening use	Any time of day	Any time of day	Any time of day	Any time of day
ageLOC Technology	✔ Targets sources of ageing*	✗ Not included	✗ Not included	✗ Not included	✗ Not included
Complementary Product	✔ Pairs with ageLOC® R² Day (daytime vitality)	No complementary system	No complementary system	No complementary system	No complementary system

Most cellular health and detoxification supplements in Australian pharmacies focus on liver support through traditional herbs, or general antioxidant defence through single-compound formulas. ageLOC® R² Night takes a more targeted approach — combining three clinically recognised plant extracts that work through distinct but complementary cellular mechanisms, specifically timed for evening use to align with the body's natural overnight renewal cycle.*

The ageLOC® R² System

ageLOC® R² Night is designed to work as part of the complete ageLOC® R² system alongside ageLOC® R² Day — the complementary daytime vitality formula. While R² Day supports physical vigour, mental acuity, and drive throughout the day, R² Night handles the overnight cellular purification that prepares your body for the next day. Together, they address both the active and restorative phases of healthy ageing — around the clock.*

How to Use

Take two (2) capsules in the evening to support cellular purification as your body renews itself overnight. Can be taken with or without food.

Keep out of reach of children. Pregnant or breastfeeding women, and people with known medical conditions, should consult a healthcare practitioner before use. Discontinue use and consult a healthcare practitioner if any adverse reactions occur. Vitamins and supplements should not replace a balanced diet.

Important: Do not take while on warfarin therapy without medical advice. Grape seed extract and other antioxidant compounds in this formula may interact with anticoagulant medications.

Frequently Asked Questions

What is cellular purification and why does it matter for ageing?
Every cell in your body continuously generates metabolic waste — by-products of energy production, damaged proteins, and oxidised molecules. The body has sophisticated systems to neutralise and remove this waste, but these systems become less efficient with age. Accumulated cellular waste contributes to the decline in cellular function we experience as ageing. Supporting these purification processes helps maintain cells in better working order for longer.*

Why should I take this at night specifically?
Your body's cellular repair and detoxification processes are most active during sleep — particularly in the later stages of deep sleep. Autophagy (cellular self-cleaning), tissue repair, and glymphatic waste clearance in the brain all peak overnight. Taking ageLOC® R² Night in the evening aligns its support with these natural biological rhythms for optimal effect.*

How does broccoli seed extract support detoxification?
Broccoli seed extract is rich in glucoraphanin, which converts to sulforaphane in the body. Sulforaphane is one of the most studied natural activators of the Nrf2 pathway — the body's master regulator of detoxification and antioxidant enzyme production. Rather than acting as a direct antioxidant, it stimulates the body's own protective enzyme systems to produce a sustained defensive response.*

What makes red orange extract different from regular vitamin C?
Red oranges (blood oranges) contain a unique combination of anthocyanins and hydroxycinnamic acids not found in regular oranges — alongside vitamin C. These compounds work through different cellular mechanisms than vitamin C alone, providing broader cellular protection particularly relevant to detoxification and environmental toxin defence.*

Can I take ageLOC® R² Night with ageLOC® R² Day?
Yes — R² Day and R² Night are specifically designed to work together as a complete system. R² Day (taken morning and midday) supports daytime vitality across physical, mental, and sexual dimensions. R² Night (taken in the evening) supports overnight cellular purification and renewal. Together they provide comprehensive ageLOC® support around the clock.*

Why does the label say not to take with warfarin?
Grape seed extract and other antioxidant compounds in this formula can potentially interact with warfarin (a blood-thinning medication), affecting how it works in the body. If you are on warfarin or any other anticoagulant therapy, always consult your GP or cardiologist before taking ageLOC® R² Night or any supplement containing grape seed extract.

How long before I notice results?
Cellular purification benefits operate gradually at a biological level. Most users find that consistent nightly use over 4–8 weeks is where the cumulative effect — feeling more refreshed in the mornings, improved general energy, and a sense of renewal — becomes most noticeable. For best results, use consistently alongside ageLOC® R² Day and a balanced, healthy lifestyle.*

Is ageLOC® R² Night suitable for vegetarians?
The capsule shell contains gelatin (animal-derived), so the current formulation is not suitable for vegetarians or vegans who avoid animal by-products. The active botanical ingredients are entirely plant-sourced.

Authoritative References

• López-Otín et al. — The Hallmarks of Aging. Cell
• Broccoli seed extract and Nrf2 pathway activation — Cancer Prevention Research
• Grape seed proanthocyanidins and cellular antioxidant defence — Free Radical Biology and Medicine
• National Health and Medical Research Council (NHMRC) — Australian Dietary Guidelines
• Glymphatic system and overnight brain waste clearance — Science

*Always read the label and follow the directions for use.