Suddenly stopping prebiotics intake can lead to a 30%-40% reduction in beneficial gut bacteria within weeks. Over 4-6 weeks, pathogenic bacteria may increase by 15%-20%. It may take 1-2 months for gut microbiome levels to return to baseline. Discontinuation often causes mood swings, such as anxiety or depression, in 70% of users.
Gut Microbiome Imbalance
Around 70% of the global population experiences varying degrees of gut microbiome changes after stopping the intake of prebiotics. After discontinuing prebiotic supplementation, the number of “beneficial bacteria” in the gut decreases by 30%-40%. Gut microbiome imbalance is directly related to over 70% of digestive system diseases.
After continuous prebiotic supplementation for 3 months, the number of beneficial bacteria in the gut can increase by about 50%-70%. If supplementation is suddenly stopped, it may take 1-2 months to return to the levels before prebiotic supplementation. After discontinuing prebiotics, the proportion of pathogenic bacteria tends to increase by about 15%-20%. Within 4-6 weeks after stopping prebiotics, many people exhibit mood fluctuations such as anxiety and depression, with 70% of patients reporting that their mood changes are directly related to gut discomfort.
The market size of prebiotics and probiotics has reached over 10 billion USD annually, and it is expected to grow to more than 20 billion USD by 2028. After discontinuing prebiotics, the activity of immune cells in the body may decrease by 20%-30%. According to a 12-week study, continuous prebiotic supplementation helped participants lose an average of 3%-5% of their body weight. After discontinuing supplementation, some participants saw weight rebound by as much as 10%.
The imbalance of the gut microbiome after stopping prebiotics is associated with negative impacts on cardiovascular health. After discontinuing prebiotics, intestinal barrier permeability increases by 10%-15%. Participants who took 3 grams of prebiotics daily had an average blood sugar reduction of 5%-7%. A global gut health study in 2019 found that prebiotic supplementation significantly improves the diversity and stability of the gut microbiome.
Digestive Discomfort
About 25%-30% of the global population experiences chronic indigestion and gastrointestinal discomfort. In the United States, indigestion costs the medical industry about 8 billion USD annually. Every year, approximately 20 million people seek medical help for gastric diseases such as gastroesophageal reflux disease (GERD) and gastritis. About 15% of the population suffers from chronic constipation. Among those with constipation symptoms, the incidence of colorectal cancer is twice as high as the general population. Nearly 30% of people over 65 experience chronic constipation symptoms.
About 40% of people experience varying degrees of bloating after meals. Indigestion and bloating symptoms are closely related to psychological stress, with approximately 55% of bloating patients reporting worsened symptoms after significant life stress. About 60% of gastrointestinal discomfort symptoms are related to gut microbiome imbalance. Every year, nearly 5 million people are hospitalized due to gut microbiome imbalance.
In the U.S., about 10 million people suffer from gastrointestinal discomfort due to high-fat diets. Excessive intake of greasy foods can increase the incidence of GERD by nearly 35%, with people who consume more than 30 grams of fat per day experiencing more frequent GERD symptoms. Every year, about 18 million Americans take antacid medications. Among long-term users of antacids, about 20% experience extra-gastrointestinal side effects.
About 40% of chronic gastrointestinal disease patients have symptoms of anxiety or depression. Women are 1.5 times more likely than men to experience gastrointestinal discomfort caused by mental stress. People who engage in at least 150 minutes of moderate-intensity exercise per week experience 30% fewer digestive discomfort symptoms than sedentary individuals.
Decreased Immune Function
About 10% of the global population will experience a decline in immune system function at some point in their lives. Among people aged 65 and older, about 40% show weakened immune responses. Globally, about 30% of the population suffers from chronic sleep deprivation, which has been proven to directly suppress the immune system. Adults with insufficient sleep may have 20% fewer white blood cells, and people who sleep less than 6 hours per night may see their immune response drop by about 30%. In groups under high stress, T-cell activity is reduced by about 25%. Long-term vitamin D deficiency can reduce immune system capacity by more than 30%.
By 2050, the global population over 65 years old is expected to account for 16% of the total population. The annual death toll from infectious diseases due to immune function decline is about 1.2 million. About 40% of diabetes patients suffer from immune system dysfunction, and cancer patients undergoing chemotherapy often experience a 40% or greater decrease in white blood cell count.
In urban areas, health costs due to immune function decline from air pollution amount to about 50 billion USD annually. Globally, about 13% of adults are obese. Obese people’s immune response after vaccination may be 20%-30% lower than that of individuals with normal weight.
Reduced Fiber Intake
About 90% of U.S. adults fail to meet the recommended daily fiber intake. Globally, about one-third of the population consumes far less fiber than recommended due to poor dietary habits. For every 10-gram reduction in fiber intake, gut microbiome diversity significantly decreases by 20%.
About 70% of cases are closely related to low-fiber diets. Constipated individuals experience a significant decline in quality of life, with symptoms occurring more than three times per week. For every 10-gram decrease in dietary fiber intake, the risk of hypertension and heart disease increases by 15%. Cardiovascular diseases cause more than 18 million deaths worldwide each year.
Globally, about 420 million people have diabetes, and 40% of them experience larger blood sugar fluctuations due to low-fiber diets. People on low-fiber diets are 30% more likely to gain weight compared to those with high-fiber diets. Approximately 600 million people are obese worldwide. Each year, about 16 million people die from cancer. About 30% of colon cancer cases are directly linked to long-term low-fiber diets.
Metabolic Changes
More than 30% of adults worldwide suffer from varying degrees of metabolic syndrome. Every year, about 2 million people develop type 2 diabetes due to metabolic syndrome. Over 40% of individuals who undergo extreme dieting experience metabolic slowdown after weight loss. For every 10% reduction in muscle mass, the BMR decreases by about 5%-10%.
Around 70% of people over 40 experience a decrease in metabolic rate. For adults over 40, their basal metabolic rate decreases by 2%-3% every decade. Increasing protein intake can significantly boost metabolism; when protein accounts for 30% of total calories, metabolism can increase by 15%. The global obese population has surpassed 600 million. People with body fat percentages over 30% have insulin sensitivity that is 20% lower than individuals of normal weight.
Among individuals who sleep less than 6 hours per night, about 40% experience metabolic abnormalities. A study found a direct relationship between the number of beneficial bacteria in the gut and metabolic rate. About 10% of adult women will experience hypothyroidism at some point in their lives, and about 30% of these individuals will develop obesity.
Mood Fluctuations
About 18% of adults worldwide experience varying degrees of mood disorders. About 40% of respondents report that mood fluctuations severely affect their work performance, with 25% stating that their work efficiency dropped by more than 20% due to unstable emotions. About 60% of women experience mood fluctuations at different stages of their menstrual cycle. About 70% of women report significant mood fluctuations, which manifest as irritability, anxiety, and depression.
People who sleep less than 6 hours per night experience mood fluctuations 50% more frequently than those who sleep more than 7 hours. About 30% of adults experience at least one night of insomnia each year, and 40% of them report that long-term insomnia leads to emotional instability. About 25% of adults report that their mood fluctuations are influenced by work stress. Around 60% of employees exhibit emotional instability when under high stress.
People who consume large amounts of high-sugar, high-fat foods experience mood fluctuations 40% more frequently than those with healthier diets. A study found that individuals who engage in aerobic exercise three times a week experience 30% fewer mood fluctuations. About 15% of mood fluctuations are linked to genetic variations.
Among seniors over 60, about 40% report fewer mood fluctuations, and about 25% of elderly individuals experience emotional instability due to a lack of effective social interaction. Around 400 million people worldwide suffer from mood disorders. About 60% of these individuals report that mood fluctuations are part of their symptoms.
Increased Difficulty in Weight
About 40% of adults face weight management issues. In the U.S., the obesity rate has reached 42.4%, a 10% increase over the past decade. Over 80% of obese individuals find it difficult to lose weight effectively through traditional diet control and exercise. Adults over 35 are 30% more likely to gain weight compared to younger individuals. In people over 40, the rate of weight gain is usually 0.5 to 1 kilogram per year. As people age, their basal metabolic rate decreases by about 5% every decade.
About 30% of obese individuals are associated with psychological stress, anxiety, or depression. Around 40% of obese individuals report that their eating habits are influenced by mood fluctuations. About 55% of full-time employees report they lack enough time to exercise, which contributes to weight gain. About 25% of adults worldwide sit for more than 8 hours per day, which makes weight management more difficult.
The annual medical costs caused by unhealthy diets have exceeded 1 trillion USD globally. Over 70% of adults eat fast food at least once a week. Genetic factors contribute to 40%-70% of obesity. Environmental pollution is positively correlated with the occurrence of obesity. Adults who sleep less than 6 hours per night are twice as likely to become obese as those who sleep regularly. People with poor sleep quality experience weight gain about 60% of the time.